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Evaluation of the Recent Dynamics for Funding Medicinal Chemistry Projects in Academia. Results of a Survey Conducted by IUPAC Division VII (Chemistry and Human Health).
J Med Chem
January 2025
Department of Chemistry, Faculty of the Exact Sciences, Bar-Ilan University, Ramat-Gan, 5290002, Israel.
Data collected from scholars across twenty-three countries over the past decade (2010-2019) reveals a 40% decrease in financial support for medicinal chemistry projects. The decline is especially notable among projects focused on small organic molecules. This drop in grants indicates a troubling trend that could jeopardize future drug development by undermining research in this crucial field.
View Article and Find Full Text PDFTargeting AXL inhibits the growth and metastasis of prostate cancer in bone.
Clin Cancer Res
January 2025
Stanford University, Palo Alto, CA, United States.
Purpose: After failing primary and secondary hormonal therapy, castration-resistant and neuroendocrine prostate cancer metastatic to the bone is invariably lethal, although treatment with docetaxel and carboplatin can modestly improve survival. Therefore, agents targeting biologically relevant pathways in PCa and potentially synergizing with docetaxel and carboplatin in inhibiting bone metastasis growth are urgently needed.
Experimental Design: Phosphorylated (activated) AXL expression in human prostate cancer bone metastases was assessed by immunohistochemical staining.
Parasitoid wasp venoms degrade imaginal discs for successful parasitism.
Sci Adv
January 2025
Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Tsukuba 305-8577, Japan.
Article Synopsis
- Parasitoid wasps, a highly diverse group of animals, use their venoms to manipulate the physiology of host larvae for their benefit.
- Researchers discovered that a specific wasp can cause the death and dysfunction of its host's tissue precursors, a process called imaginal disc degradation (IDD).
- The study identified two venom proteins crucial for IDD, showing how the wasp's venom strategically ensures the host grows but inhibits its transformation into adulthood.
The effects of prenatal administration of tumor necrosis factor-α on osteocalcin and RANK expression in newborn mice.
J Mol Histol
January 2025
Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Tumor necrosis factor-α (TNF-α) induces a multitude of actions and consequences in bone and cartilage resorption and immune response augmentation. In this research, we aimed to investigate the effects of TNF-α on osteogenesis parameters in newborn mice. Experimental research was conducted on 42 pregnant mice, dividing into seven groups as follows: control (no injection), vehicle 1 (PBS injection on 7-9th pregnancy days (PD)), vehicle 2 (PBS injection during pregnancy), experimental 1 (injection of 10 ng/kg of TNF-α on 7-9th PD), experimental 2 (injection of 100 ng/kg of TNF-α on 7-9th PD), experimental 3 (injection of 10 ng/kg of TNF-α during pregnancy) and experimental 4 (injection of 100 ng/kg of TNF-α during pregnancy).
View Article and Find Full Text PDFFormulation of Ethyl Cellulose Nanoparticles Encapsulated with Osthole Provides Long-Lasting Plant Protection against a Major Pest Mite.
ACS Appl Mater Interfaces
January 2025
Institute of Plant Protection, Shandong Academy of Agricultural Sciences, Jinan 250100, China.
The broader use of botanical pesticides has been limited by shorter residual activity on plants, slower onset of action, and higher costs compared with conventional pesticides. These challenges could be overcome by the development of simple, cost-effective, and long-lasting preventive nanocomposites for botanical pesticides. In this study, we successfully developed a low-cost ethyl cellulose (EC)-based delivery system for the botanical pesticide osthole (OST), designed to provide extended preventive protection against infestations.
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