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Coma and confirmed epileptiform activity induced by Amanita pantherina poisoning.
Toxicon
December 2024
Bergamo Poison Center, ASST Papa Giovanni XXIII Hospital, Bergamo, Italy.
Amanita pantherina poisoning is a rare event poorly described. The clinical picture is usually associated with the one of A. muscaria, but A.
View Article and Find Full Text PDFReview of the Hazards and Contraindications of Etomidate.
Int J Toxicol
November 2024
Key Laboratory of Tropical Translational Medicine of Ministry of Education, Department of Forensic Medicine, Hainan Provincial Tropical Forensic Engineering Research Center, Hainan Medical University, Haikou, China.
Etomidate, an ultrashort-acting non-barbiturate sedative derived from imidazole, exerts potent inhibitory effects on the central nervous system. It is commonly employed for the induction of intravenous general anaesthesia or assisted anaesthesia. Recently, etomidate has emerged as an alternative to narcotics and novel psychoactive substances, leading to an increasing trend of abuse.
View Article and Find Full Text PDFSynergistic polytherapy for the broad-spectrum treatment of chemically-induced seizures in rats.
Toxicol Appl Pharmacol
December 2024
Department of CBRN Protection, TNO Defence, Safety and Security, Lange Kleiweg 137, 2288 GJ Rijswijk, the Netherlands.
Chemically-induced seizures, as a result of exposure to a neurotoxic compound, present a serious health concern. Compounds can elicit seizure activity through disruption of neuronal signaling by neurotransmitters, either by mimicking, modulating or antagonizing their action at the receptor or interfering with their metabolism. Benzodiazepines, such as diazepam and midazolam, and barbiturates are the mainstay of treatment of seizures.
View Article and Find Full Text PDFEvaluating the detection of barbiturates in dried blood spots: A comparative analysis using gas chromatography-mass spectrometry, gas chromatography-tandem mass spectrometry, and liquid chromatography-tandem mass spectrometry with different extraction methods.
J Chromatogr A
November 2024
Department of Forensic Toxicology, Academy of Forensic Science, Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Science Platform, Key Laboratory of Forensic Sciences, Ministry of Justice, No.1347 Guangfuxi Road, Shanghai 200063, PR China. Electronic address:
Rapid and accurate characterization and quantitation of blood barbiturates and their combination drugs are very important for the clinical treatment of acute barbiturate poisoning. A comparison of dried blood spot (DBS) and traditional liquid-liquid extraction (LLE) in the pre-treatment stage, as well as a comparison of gas chromatography-mass spectrometry (GC-MS), gas chromatography-tandem mass spectrometry (GC-MS/MS), and liquid chromatography-tandem mass spectrometry (LC-MS/MS) as instrumental analysis methods, revealed differences in the analysis results of barbiturates and their combination drugs under different conditions. Based on these findings, we introduce a DBS-GC-MS/MS method.
View Article and Find Full Text PDFRational analysis of data from LC-MS/MS: new insights in acylcarnitines as biomarkers for brain disorders or neurotoxicity.
Front Pharmacol
August 2024
Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Article Synopsis
- LC-MS/MS-based metabolomics is used to study disease biomarkers, specifically through analyzing the effects of Phenobarbital (PHB) poisoning on acylcarnitine levels in plasma and brain tissues.
- The study effectively employed various statistical methods, including PCA and OPLS-DA, to assess the dose-response relationships and identify potential biomarkers for neurotoxicity.
- A total of 14 and 11 potential toxicity biomarkers were identified through different screening strategies, with overlap seen in specific acylcarnitines when considering dose-response relationships.
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