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Blood parameters in pediatric myelin oligodendrocyte glycoprotein antibody-associated disorders.
Eur J Paediatr Neurol
May 2024
Division of Pediatric Neurology, Department of Pediatrics I, Medical University of Innsbruck, Innsbruck, Austria. Electronic address:
Article Synopsis
- The study focuses on comparing blood parameters in children with myelin oligodendrocyte glycoprotein antibody-associated disorders (MOGAD), AQP4-IgG-positive neuromyelitis optica spectrum disorders (NMOSD), multiple sclerosis (MS), and healthy controls to better understand disease activity.
- Researchers analyzed complete blood counts and various ratios (like NLR and PLR) during different disease phases: clinical attack, acute treatment, and remission across a cohort of 174 children and adolescents.
- Key findings revealed elevated leukocyte counts in MOGAD during clinical attacks, while other blood parameters like NLR and PLR showed different trends, suggesting these measures could aid in assessing disease activity and distinguishing between disease
Summary of Safety and Efficacy of COVID Vaccination in Patients with Multiple Sclerosis.
Eur Neurol
September 2023
Avenier, Centres of Vaccination and Travel Medicine, Brno and Ostrava, Czechia.
Article Synopsis
- The SARS-CoV-2 pandemic poses significant challenges for everyday life, especially for patients with multiple sclerosis (MS) who are vulnerable due to their treatments with disease-modifying therapies (DMTs).
- Understanding vaccine effectiveness and safety for MS patients, especially regarding potential risks and neurological impacts, is essential since these patients might be at risk of disease relapses following infections.
- Vaccination is recommended for MS patients not in an active disease phase, as it offers some protection despite concerns about reduced immune responses due to certain DMTs, and timing for vaccinations and DMT regimen is crucial for optimizing the vaccine's effectiveness.
COVID-19 and the risk of CNS demyelinating diseases: A systematic review.
Front Neurol
September 2022
Division of Neuroimmunology and Neuroinfectious Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Background: Viral infections are a proposed possible cause of inflammatory central nervous system (CNS) demyelinating diseases, including multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). During the past 2 years, CNS demyelinating events associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have been reported, but causality is unclear.
Objective: To investigate the relationship between CNS demyelinating disease development and exacerbation with antecedent and/or concurrent SARS-CoV-2 infection.
Clinical failure of natalizumab in multiple sclerosis: Specific causes and strategy.
Rev Neurol (Paris)
December 2021
Service de neurologie, sclérose en plaques, pathologies de la myéline et neuro-inflammation, hôpital Neurologique Pierre Wertheimer, hospices civils de Lyon, 69677 Lyon/Bron, France; Université Claude Bernard Lyon 1, faculté de médecine Lyon Est, 69000 Lyon, France; Inserm 1028 et CNRS UMR5292, Centre des neurosciences de Lyon, Observatoire français de la sclérose en plaques, 69003 Lyon, France. Electronic address:
Background: Natalizumab is a very effective treatment of multiple sclerosis (MS). Failure is rare and should lead to consider some specific etiologies. The purpose of our study was to describe causes of subacute neurological events under natalizumab.
View Article and Find Full Text PDF[Spermatic cord lipoma].
Actas Urol Esp
March 1998
Servicio de Urología, Hospital Comarcal de la Selva, Blanes (Girona).
In spite of being the most frequent tumour in this location, together with adenomatoid tumours, the spermatic cord lipoma is a very rare entity (30-35% each). The etiology is unknown but linked to a constitutional factors, obesity, an its presentation is more frequent in the fifth or sixth decade of life. It progresses always as an asymptomatic tumour, usually unilateral, showing a swift growth to masses larger than 10 cm.
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