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Hyperuricemia - consequences of not initiating therapy. Benefits and drawbacks of treatment.
Reumatologia
July 2024
Voivodeship Hospital, Wloclawek, Poland.
Hyperuricemia, characterized by elevated levels of uric acid in the body, is associated with several health risks, including gout, urolithiasis and cardiovascular disease. Although treatment options are available, they can lead to hypersensitivity reactions, particularly with allopurinol therapy. This paper provides a comprehensive review of the consequences of hyperuricemia, the need for treatment and the potential adverse effects of allopurinol, illustrated by a case study.
View Article and Find Full Text PDFPharmacotherapy and Stone Mineral Subtype Influence Long-Term Recurrence Rates in Calcium Stone Formers.
Kidney360
September 2024
Department of Urology, University of Florida, Gainesville, FL.
Article Synopsis
- Long-term data on calcium stone formers is scarce, but this study emphasizes the protective role of medical therapy (MT) in reducing future stone formation in high-risk patients over time.
- The study tracked patients with calcium-oxalate and calcium-phosphate stones for 10 to 12 years, focusing on those who received MT, which includes medications like thiazides and potassium citrate.
- Results showed that those on MT experienced fewer stone occurrences (21.3%) compared to those not on treatment (37.5%) over a mean follow-up of 10.6 years, with a notable difference in events based on stone subtype.
ALLOPURINOL TREATMENT IMPROVES INSULIN RESISTANCE IN NON-DIABETIC PATIENTS WITH RENAL STONE.
Georgian Med News
April 2024
1College of Medicine, University of Mosul, Iraq.
Hyperuricemia is an objective risk factor of derangement of fasting serum glucose and type 2 diabetes (T2D), yet whether hyperuricemia has a causative influence on insulin resistance is still debatable. In this study, we tested the hypothesis that lowering uric acid in hyperuricemic nondiabetic subjects might improve insulin resistance. Patients with renal stone and hyperuricemia (n=15) were recruited from the private clinic of Ib-Sina Local Teaching Hospital in Mosul city and prospectively placed on allopurinol (300mg/day) for 6 months.
View Article and Find Full Text PDFAllopurinol use leading to xanthine nephrolithiasis in pediatric tumor lysis syndrome: a case series.
Pediatr Nephrol
November 2024
Indiana University Department of Pediatrics, Division of Nephrology, Riley Children's Hospital, 705 Riley Drive, Indianapolis, IN, 46202, USA.
Tumor lysis syndrome (TLS) is a life-threatening metabolic disorder caused by massive tumor lysis. Allopurinol, a xanthine oxidase inhibitor, is initiated during chemotherapy to prevent hyperuricemia and subsequent acute kidney injury (AKI). We report two cases of xanthine nephrolithiasis during TLS in newly diagnosed hematologic malignancy patients receiving prophylactic allopurinol.
View Article and Find Full Text PDFBenzyl-isoquinoline alkaloids rich extract of Coptis teeta Wall., exhibit potential efficacy in calcium-oxalate and uric-acid linked metabolic disorders.
Fitoterapia
September 2024
Pharmacognosy Division, CSIR-National Botanical Research Institute, Lucknow, UP, India. Electronic address:
Coptis teeta Wall., an endangered but valuable medicinal species having various folklore uses in Indian and Chinese Traditional system of medicine. Its distribution is restricted to India, China and Tibet.
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