Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1212256 | PMC |
| http://dx.doi.org/10.1093/genetics/62.1.123 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The B Chromosome of Pseudococcus viburni: A Selfish Chromosome that Exploits Whole-Genome Meiotic Drive.
Genome Biol Evol
January 2025
School of Biological Sciences, Institute of Ecology and Evolution, The University of Edinburgh, Edinburgh EH9 3FL, UK.
Meiosis is generally a fair process: each chromosome has a 50% chance of being included into each gamete. However, meiosis can become aberrant with some chromosomes having a higher chance of making it into gametes than others. Yet, why and how such systems evolve remains unclear.
View Article and Find Full Text PDFDiversification and recurrent adaptation of the synaptonemal complex in Drosophila.
PLoS Genet
January 2025
Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada.
The synaptonemal complex (SC) is a protein-rich structure essential for meiotic recombination and faithful chromosome segregation. Acting like a zipper to paired homologous chromosomes during early prophase I, the complex is a symmetrical structure where central elements are connected on two sides by the transverse filaments to the chromatin-anchoring lateral elements. Despite being found in most major eukaryotic taxa implying a deeply conserved evolutionary origin, several components of the complex exhibit unusually high rates of sequence turnover.
View Article and Find Full Text PDFSpatiotemporal dynamics of early oogenesis in pigs.
Genome Biol
January 2025
College of Life Sciences, Key Laboratory of Animal Reproduction and Biotechnology in Universities of Shandong, Qingdao Agricultural University, Qingdao, 266109, China.
Background: In humans and other mammals, the process of oogenesis initiates asynchronously in specific ovarian regions, leading to the localization of dormant and growing follicles in the cortex and medulla, respectively; however, the current understanding of this process remains insufficient.
Results: Here, we integrate single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) to comprehend spatial-temporal gene expression profiles and explore the spatial organization of ovarian microenvironments during early oogenesis in pigs. Projection of the germ cell clusters at different stages of oogenesis into the spatial atlas unveils a "cortical to medullary (C-M)" distribution of germ cells in the developing porcine ovaries.
Recombination landscape and karyotypic variations revealed by linkage mapping in the grapevine downy mildew pathogen Plasmopara viticola.
G3 (Bethesda)
January 2025
MYCSA, INRAE, Villenave d'Ornon F-33140, France.
Plasmopara viticola, the causal agent of grapevine downy mildew, is a biotrophic oomycete engaged in a tight coevolutionary relationship with its host. Rapid adaptation of the pathogen is favored by annual sexual reproduction that generates genotypic diversity. With the aim of studying the recombination landscape across the P.
View Article and Find Full Text PDFInvestigation of an MCM8 gene variant in women with premature ovarian insufficiency.
Einstein (Sao Paulo)
November 2024
Centro Universitário FMABC, Santo André, SP, Brazil.
Article Synopsis
- - The MCM8 gene is crucial for repairing DNA breaks and maintaining cell health, and its dysfunction can lead to cell death, especially in relation to primary ovarian insufficiency.
- - The study aimed to evaluate a specific variant of the MCM8 gene (NG_042869.1:g.40270G>A) in women with primary ovarian insufficiency by comparing samples from affected individuals to those from a control group.
- - Results showed the variant was present in one sample from the case group but absent in the control group, indicating it may be a rare, pathogenic variant associated with primary ovarian insufficiency in the studied population.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!