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Liver Transplantation and the Older Adults Candidate: Perioperative Considerations.

Clin Geriatr Med

February 2025

Anestesia e Rianimazione dei Trapianti e Chirurgia Maggiore, Azienda Ospedaliero Universitaria delle Marche, Via Conca 71, 60020, Ancona, Italy; Azienda Ospedaliero Universitaria "Ospedali Riuniti", Via Conca 71, 60020, Ancona, Italy.

Pioneered by Thomas Starzl in the early 1970s, liver transplant (LT) is nowadays often considered a final intervention and standard of care to cure many forms of acute and chronic end-stage liver diseases. Started in recipients younger than 60 years old, LT indications are now much broader, and at least, one-fifth of the candidates are older than 65 years. Problems associated with ageing and frailty in LT recipients and their impact on the entire perioperative course are discussed according to a modern anesthesiological perspective and the anesthesiologist covering the role of the perioperative (transplant) physician.

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: Anesthesiologists come into contact with patients under palliative care in different clinical settings. They also routinely encounter these patients in their primary field of work, the operating room. Patients receiving palliative care who are scheduled for surgery will pose unique challenges in perioperative management, often presenting with advanced disease and with different psychosocial and ethical issues.

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Article Synopsis
  • * A consensus meeting in March 2024, attended by 28 experts and stakeholders, aimed to standardize research protocols for studying neuropathic pain using human peripheral tissues.
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  • * After her surgery, her coughing got really bad, and even strong medications couldn't help her feel better.
  • * The case shows that doctors need to carefully plan how to help patients with serious cough problems before and during surgery.
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  • * A study of 17 patients (mean age 62) who underwent surgeries showed that while intraoperative venous air embolism (VAE) occurred in some cases, it did not lead to complications or impact surgery outcomes.
  • * The findings suggest that using the semi-sitting position for these types of surgeries is both safe and effective, with most patients achieving partial or complete independence post-surgery.
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