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Changeover method for biosafety cabinets using ozone gas.
PLoS One
January 2025
Center for Stem Cell and Regenerative Medicine, Institute of Science Tokyo, Bunkyo-ku, Tokyo, Japan.
This study evaluated the effectiveness of a biosafety cabinet equipped with an ozone generator, particularly during the transition periods between the production of cell products. As living cell products cannot undergo sterilization, maintaining an aseptic manufacturing environment is paramount. Raw materials, often derived from human tissues, are frequently contaminated with various resident bacteria, necessitating environmental resets after each process.
View Article and Find Full Text PDFNeomorphic leukemia-derived mutations in the TET2 enzyme induce genome instability via a substrate shift from 5-methylcytosine to thymine.
Proc Natl Acad Sci U S A
February 2025
Center for Medical Research and Innovation, Shanghai Pudong Hospital, Institutes of Biomedical Sciences, Chinese Academy of Medical Sciences (RU069), Medical College of Fudan University, Shanghai 201399, China.
Ten-eleven translocation (TET) enzymes oxidize 5-methylcytosine (mC) in DNA, contributing to the regulation of gene transcription. Diverse mutations of TET2 are frequently found in various blood cancers, yet the full scope of their functional consequences has been unexplored. Here, we report that a subset of TET2 mutations identified in leukemia patients alter the substrate specificity of TET2 from acting on mC to thymine.
View Article and Find Full Text PDFGrowth decline in European beech associated with temperature-driven increase in reproductive allocation.
Proc Natl Acad Sci U S A
February 2025
Forest Biology Center, Institute of Environmental Biology, Faculty of Biology, Adam Mickiewicz University, 61-614 Poznan, Poland.
Climate change is impacting forests in complex ways, with indirect effects arising from interactions between tree growth and reproduction often overlooked. Our 43-y study of European beech () showed that rising summer temperatures since 2005 have led to more frequent seed production events. This shift increases reproductive effort but depletes the trees' stored resources due to insufficient recovery periods between seed crops.
View Article and Find Full Text PDFOne-Year Real-World Outcomes of Ab-Externo Gel Stent Placement From the EXPAND Study.
J Glaucoma
January 2025
Wills Eye Hospital Glaucoma Service, Philadelphia, PA, USA.
Prcis: In the real-world, retrospective, EXPAND study of consecutive adults with glaucoma, ab-externo gel stent implantation effectively lowered intraocular pressure (34%) and the medication burden (61%), with transient/self-resolving hypotony as the most frequent adverse event (28%).
Purpose: To assess effectiveness and safety of ab-externo gel stent (GS) implantation in glaucoma.
Methods: Multicenter, real-world, retrospective study.
Real-world switching patterns and associated characteristics in patients with psoriasis treated with biologics.
Arch Dermatol Res
January 2025
Department of Nursing, University of Peloponnese, Tripoli, 22100, Greece.
Multiple parameters define the treatment course with biologics for a psoriatic patient while treatment switches are often associated with worse prognosis. The purpose of this study was to describe the switching patterns of biologics for psoriasis in the Greek market landscape and to detect associated factors that may impact the evolvement of selected therapy. This is a retrospective cohort study using data recorded in the nationwide digital prescription database of Greece.
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