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A numerical simulation study of airway flow: Impact of bronchial stenosis.
Med Eng Phys
March 2025
Jiangsu Key Laboratory for Design and Manufacture of Micro/Nano Biomedical Instruments Micro-Tech (Nanjing) Co., Ltd., Nanjing, Jiangsu Province 210032, PR China.
Obstructive lung diseases, marked by airway stenosis, are chronic and pose significant mortality risks. This study aims to analyze airflow patterns in obstructed bronchi, comparing them to healthy airways during tidal breathing to improve our comprehension of disease effects on respiratory function. The current studies mostly overlook the specific morphology of the patient's upper airway or the elastic deformation of the airway soft tissues, which results in the existing results not being sufficient to effectively guide surgical treatment.
View Article and Find Full Text PDF[Effect of inhaled corticosteroids on airway remodeling in patients with mild asthma].
Zhonghua Jie He He Hu Xi Za Zhi
March 2025
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510030, China.
To evaluate the effect of inhaled corticosteroids on airway remodeling in patients with mild asthma. In this single-arm, open-label, single-center, prospective exploratory study, we enrolled patients with mild asthma from January 2019 to December 2020 at the First Affiliated Hospital of Guangdong Pharmaceutical University. A total of 15 patients with mild asthma were included in this study.
View Article and Find Full Text PDFCase report: Lobular capillary hemangioma of the right main bronchus: a rare case with calcified and cystic lymph nodes.
Front Med (Lausanne)
February 2025
Department of Respiratory and Critical Care Medicine, Guangyuan Central Hospital, Guangyuan, Sichuan, China.
Lobular capillary hemangioma (LCH), typically a benign vasoproliferative lesion of the skin or mucosal surfaces, is exceptionally rare in the trachea. Now, we present the second reported case of LCH found in the right intermediate bronchus, characterized by calcification within the lesion and cystic changes. These distinctive features should alert clinicians to consider LCH in the differential diagnosis of other benign vascular tumors and mediastinal lymphadenopathy, particularly when calcified and cystic lesions are observed.
View Article and Find Full Text PDFOxidative Stress and Epithelial-Mesenchymal Transition: The Impact of Ubiquitin C-terminal Hydrolase L1 in Cigarette Smoke-Induced COPD.
Lung
February 2025
Department of Pulmonary and Critical Care Medicine, Northern Jiangsu People's Hospital, Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu, China.
Purpose: Cigarette smoke (CS) has been demonstrated to mediate oxidative stress (OS) and epithelial-mesenchymal transition (EMT) in bronchial epithelial cells, thereby contributing to airway remodeling in chronic obstructive pulmonary disease (COPD). Studies have shown upregulation of Ubiquitin C-terminal hydrolase L1 (UCHL1), a deubiquitinating enzyme, in the airway epithelium of smokers. Many studies indicate that UCHL1's regulation of EMT and OS has a complex role in various cell types, including respiratory epithelium.
View Article and Find Full Text PDFComparative toxicity study of three surface-modified titanium dioxide nanoparticles following subacute inhalation.
Part Fibre Toxicol
February 2025
Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Hannover, Germany.
Background: This study aimed to compare the toxic effects of three different titanium dioxide nanoparticles encoded in the European nanomaterial repository as NM-103 (rutile, hydrophobic), NM-104 (rutile, hydrophilic), and NM-105 (anatase/rutile, hydrophilic), suggesting different toxic potentials after uptake in the lungs. Wistar rats were exposed by nose-only inhalation to aerosol concentrations of 3, 12 and 48 mg/m for 4 weeks. This dosing scheme should induce non, partial and complete lung overload.
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