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Urologia
September 2024
Institut national de nutrition et de technologie alimentaire de Tunis, service A, Tunis, Tunisia.
Background: hypovitaminosis D is frequent in kidney transplant recipient (KTR) patients and is associated with deleterious effects both at the bone and extraosseous levels. Treatment with cholecalciferol is effective for the normalization of 25(OH)D, demonstrating a beneficial effect on the calcium-tropic axis in other populations; however, its effect on the PTH/vitamin D/calcium and FGF23/klotho/phosphorus axis in RTR has not been reported. The aim of this study was to evaluate the effect of normalization of serum 25(OH)D concentrations on the PTH/vitamin D/calcium-FGF23/klotho/phosphorus axis in KTR treated with cholecalciferol, as well as the association between the components of this axis.
View Article and Find Full Text PDFOsteoporos Int
April 2023
Division of Nephrology & Bone and Mineral Metabolism, University of Kentucky, Lexington, USA.
Unlabelled: The impact of urine calcium on kidney, bone, and cardiovascular systems in osteoporosis is not well-known. In this 7-year-follow-up study, high urine calcium did not affect kidney function but increased risk of kidney stones, while low urine calcium increased cardiovascular diseases. Maintaining normal urine calcium is beneficial for bone health.
View Article and Find Full Text PDFNefrologia (Engl Ed)
November 2023
Advicenne, Nîmes, France.
Background And Objectives: ADV7103 is a new prolonged-release treatment for distal renal tubular acidosis (dRTA), containing potassium citrate and potassium bicarbonate. Since acidosis may affect bone mineral contents, the effects of ADV7103 on bone mineral density (BMD) and growth in patients with dRTA over 24 months were evaluated.
Patients And Methods: Thirty patients (24 paediatric patients and 6 adults) were included in an open-label extension study after a phase II/III trial.
Cureus
November 2022
Pediatric Urology, University of Alabama at Birmingham, Birmingham, USA.
Background The incidence of nephrolithiasis during childhood has increased significantly over recent decades. Some studies indicate a rapid rise in adolescents, particularly in African American women. This study serves to identify trends in symptomatic pediatric nephrolithiasis presentations to the emergency department (ED) as a result of increasing incidence and to determine associations between demographic variables at our single-site tertiary pediatric hospital in the Southeast United States.
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