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Ecotoxicol Environ Saf
December 2024
Department of Occupational Medical and Environmental Health, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 211166, China; Department of Public Health, Kangda College of Nanjing Medical University, Lianyungang, 320700, China. Electronic address:
Silicosis is a disease caused by prolonged exposure to silica dust. It is the most typical, rapidly progressive, and fatal form of pneumoconiosis. Currently, there is no specific medication available for the treatment of silicosis.
View Article and Find Full Text PDFClin Cosmet Investig Dermatol
November 2024
Department of Ophthalmology. The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, ZheJiang Province, People's Republic of China.
The high incidence of disability and fatality rates associated with chronic diabetic wounds are difficult problems in the medical field. The steady-state and regular changes of the microenvironment in and around the wound provide good conditions for wound healing and achieve a dynamic and complex process of wound healing.The pH value and ionic environment composed of a variety of ions in wound are important factors affecting the wound microenvironment, and there are direct or indirect connections between them.
View Article and Find Full Text PDFInt J Food Microbiol
January 2025
Technological Federal University of Paraná, Paraná, Av. dos Pioneiros 3131, Londrina CEP 86036-370, Brazil. Electronic address:
Radiat Res
January 2025
Free Radical and Radiation Biology Program, B180 Medical Laboratories, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa 52242.
Diffuse intrinsic pontine gliomas (DIPG) are highly aggressive and treatment-resistant childhood primary brainstem tumors with a median survival of less than one year after diagnosis. The prevailing standard of care for DIPG, radiation therapy, does not prevent fatal disease progression, with most patients succumbing to this disease 3-8 months after completion of radiation therapy. This underscores the urgent need for novel combined-modality approaches for enhancing therapy responses.
View Article and Find Full Text PDFBiomater Res
October 2024
Medicinal Materials Research Center, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Hwarang-ro 14-gil 5, Seongbuk-gu, Seoul 02792, Republic of Korea.
The recent discovery of cuproptosis, a novel copper-ion-induced cell death pathway, has suggested the novel therapeutic potential for treating heterogeneous and drug-resistant cancers. Currently, copper ionophore-based therapeutics have been designed to treat cancers, utilizing copper ions as a strategic tool to impede tumor proliferation and promote cellular demise. However, limitations of copper ionophore-based therapies include nontargeted delivery of copper ions, low tumor accumulation, and short half-life.
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