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Optical coherence tomography angiography in patients with bipolar disorder and major depressive disorder.
J Affect Disord
September 2024
Moscow Research and Clinical Center for Neuropsychiatry, Moscow Healthcare Department, Moscow, Russian Federation; S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation.
Background: Cerebral microvascular dysfunction is a promising area for research into the pathogenesis of major depressive disorder (MDD) and bipolar disorder (BD). Despite the scientific and clinical potential of studying microvascular dysfunction, progress in this area has long been hampered by the lack of methods to study microvessels intravitally.
Aims: The aim of the present study was to search for potential optical coherence tomography (OCT) and OCT-angiography (OCTA) biomarkers of BD and MDD.
Long-term Intravital Investigation of an Orthotopic Glioma Mouse Model Optical Coherence Tomography Angiography.
In Vivo
April 2024
State Key Laboratory of Vaccines for Infectious Diseases, Center for Molecular Imaging and Translational Medicine, Xiang An Biomedicine Laboratory, School of Public Health, Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), Xiamen University, Xiamen, P.R. China;
Background/aim: Probing brain tumor microvasculature holds significant importance in both basic cancer research and medical practice for tracking tumor development and assessing treatment outcomes. However, few imaging methods commonly used in clinics can noninvasively monitor the brain microvascular network at high precision and without exogenous contrast agents in vivo. The present study aimed to investigate the characteristics of microvasculature during brain tumor development in an orthotopic glioma mouse model.
View Article and Find Full Text PDFFluorescence Angiography with Dual Fluorescence for the Early Detection and Longitudinal Quantitation of Vascular Leakage in Retinopathy.
Biomedicines
January 2023
Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Background: Diabetic retinopathy (DR) afflicts more than 93 million people worldwide and is a leading cause of vision loss in working adults. While DR therapies are available, early DR development may go undetected without treatment due to the lack of sufficiently sensitive tools. Therefore, early detection is critically important to enable efficient treatment before progression to vision-threatening complications.
View Article and Find Full Text PDFMultimodal evaluation of an interphotoreceptor retinoid-binding protein-induced mouse model of experimental autoimmune uveitis.
Exp Mol Med
March 2022
Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.
Article Synopsis
- The study investigates the vascular changes in a mouse model of experimental autoimmune retinal uveitis (EAU) induced by interphotoreceptor retinoid-binding protein (IRBP) using various imaging techniques.
- Results showed significant inflammation and damage to the retina, including immune cell infiltration and impaired retinal blood flow, particularly three weeks after immunization.
- The findings indicate that the activation of inflammatory cells and their impact on blood vessel function may play a crucial role in the development of vascular issues in noninfectious uveitis, enhancing our understanding of this condition.
Effect of Surgical Technique on the Microstructure and Microcirculation of the Small Intestine Stump during Delayed Anastomosis: Multimodal OCT Data.
Sovrem Tekhnologii Med
March 2022
Professor, Head of the Scientific Laboratory of Optical Coherence Tomography, Research Institute of Experimental Oncology and Biomedical Technologies; Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russia.
Unlabelled: was to use multimodal optical coherence tomography (MM OCT) to evaluate microstructure and microcirculation in the proximal and distal sections of the intestine relative to the resected area in acute mesenteric ischemia.
Materials And Methods: The study was carried out using three groups of male Wistar rats weighing 270-435 g (n=18). Acute occlusive arterial ischemia of the small intestine was initiated in all animals.
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