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Mitigating the charging rush hour.
Heliyon
November 2024
Institute of Environmental Systems Sciences, University of Graz, Merangasse 18, Graz, 8010, Austria.
Great effort is put into making our mobility system more sustainable in order to mitigate climate change. One corner stone of this endeavour is the transition from internal combustion engines to electric engines for private cars. This transition, however, introduces new challenges, especially regarding the demand for electrical energy from renewable sources.
View Article and Find Full Text PDFThe emerging risk of overdiagnosis in rheumatoid arthritis and polymyalgia rheumatica.
Lancet Rheumatol
September 2024
Hub for Collaborative Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Article Synopsis
- * Recent discussions advocate for screening patients with polymyalgia rheumatica for giant cell arteritis and those with rheumatoid arthritis for interstitial lung disease, but these benefits must be balanced against potential harms.
- * Harms of overdiagnosis include unnecessary follow-ups for incidental findings, financial burdens of screening, risks of overtreatment, and the emotional stress of a new diagnosis, highlighting the need for research to better assess risks and benefits of such screenings.
Tools to implement measurement-based care (MBC) in the treatment of opioid use disorder (OUD): toward a consensus.
Addict Sci Clin Pract
February 2024
Center for Clinical Trials Network, National Institute on Drug Abuse, National Institutes of Health, 11601 Landsdown Street (3WF), Bethesda, MD, 20892, USA.
Background: The prevalence and associated overdose death rates from opioid use disorder (OUD) have dramatically increased in the last decade. Despite more available treatments than 20 years ago, treatment access and high discontinuation rates are challenges, as are personalized medication dosing and making timely treatment changes when treatments fail. In other fields such as depression, brief measures to address these tasks combined with an action plan-so-called measurement-based care (MBC)-have been associated with better outcomes.
View Article and Find Full Text PDFHuman disease-specific cell signatures in non-lesional tissue in Multiple Sclerosis detected by single-cell and spatial transcriptomics.
bioRxiv
December 2023
Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center.
Recent investigations of cell type changes in Multiple Sclerosis (MS) using single-cell profiling methods have focused on active lesional and peri-lesional brain tissue, and have implicated a number of peripheral and central nervous system cell types. However, an important question is the extent to which so-called "normal-appearing" non-lesional tissue in individuals with MS accumulate changes over the lifespan. Here, we compared post-mortem non-lesional brain tissue from donors with a pathological or clinical diagnosis of MS from the Religious Orders Study or Rush Memory and Aging Project (ROSMAP) cohorts to age- and sex-matched brains from persons without MS (controls).
View Article and Find Full Text PDFApoptosis recognition receptors regulate skin tissue repair in mice.
Elife
December 2023
Dept. of Molecular Cellular and Developmental Biology, Yale University, New Haven, United States.
Apoptosis and clearance of apoptotic cells via efferocytosis are evolutionarily conserved processes that drive tissue repair. However, the mechanisms by which recognition and clearance of apoptotic cells regulate repair are not fully understood. Here, we use single-cell RNA sequencing to provide a map of the cellular dynamics during early inflammation in mouse skin wounds.
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