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Potential Use of GLP-1 and GIP/GLP-1 Receptor Agonists for Respiratory Disorders: Where Are We at?
Medicina (Kaunas)
December 2024
School of Medicine, PROMISE Department of Health Promotion Sciences Maternal and Infantile Care, Internal Medicine and Medical Specialties, University of Palermo, 90133 Palermo, Italy.
Chronic respiratory disorders are the third leading cause of mortality globally. Consequently, there is a continuous pursuit of effective therapies beyond those currently available. The therapeutic potential of the glucagon-like peptide-1 (GLP-1) and the glucose-dependent insulinotropic polypeptide/GLP-1 (GIP/GLP-1) receptor agonists extends beyond the regulation of glycemia, including glucometabolic, cardiovascular, and renal effects, rendering them viable candidates, due to their mechanisms of action, for the possible treatment of respiratory disorders.
View Article and Find Full Text PDFGLP-1 enhances β-cell response to protein ingestion and bariatric surgery amplifies it.
Obesity (Silver Spring)
January 2025
Division of Diabetes, Department of Medicine, University of Texas Health at San Antonio, San Antonio, Texas, USA.
Article Synopsis
- The study explores the role of glucagon-like peptide-1 (GLP-1) in regulating insulin and glucose metabolism during protein consumption in humans with different surgical weight-loss procedures (gastric bypass and sleeve gastrectomy).
- Blocking the GLP-1 receptor negatively impacted insulin sensitivity and glucose levels during protein intake, particularly in post-surgery patients compared to non-operated controls.
- The findings suggest that GLP-1 has both pancreatic and non-pancreatic functions during digestion, and these effects are heightened after bariatric surgery.
Effect of bariatric surgery on HDL-mediated cholesterol efflux capacity.
Front Cardiovasc Med
November 2024
Nephrology Department, Hospital del Mar, Barcelona, Spain.
Background: Bariatric surgery (BS) is the most effective intervention for severe obesity, leading to sustained weight loss, reduced obesity-related comorbidities, and cardiovascular mortality.
Aim: To assess changes in high-density lipoprotein (HDL) functions [cholesterol efflux capacity (CEC) and anti-inflammatory capacity] at different follow-up times in patients with severe obesity undergoing BS.
Methods: A prospective observational study within a cohort of consecutively enrolled patients with severe obesity scheduled to undergo BS.
Manipulation of Post-Prandial Hyperglycaemia in Type 2 Diabetes: An Update for Practitioners.
Diabetes Metab Syndr Obes
August 2024
Department of Surgery and Cancer, Imperial College London, London, UK.
This review paper explores post-prandial glycemia in type 2 diabetes. Post-prandial glycemia is defined as the period of blood glucose excursion from immediately after the ingestion of food or drink to 4 to 6 hours after the end of the meal. Post-prandial hyperglycemia is an independent risk factor for cardiovascular disease with glucose "excursions" being more strongly associated with markers of oxidative stress than the fasting or pre-prandial glucose level.
View Article and Find Full Text PDFImpacts of dietary animal and plant protein on weight and glycemic control in health, obesity and type 2 diabetes: friend or foe?
Front Endocrinol (Lausanne)
August 2024
Adelaide Medical School and Centre of Research Excellence in Translating Nutritional Science to Good Health, University of Adelaide, Adelaide, SA, Australia.
It is well established that high-protein diets (i.e. ~25-30% of energy intake from protein) provide benefits for achieving weight loss, and subsequent weight maintenance, in individuals with obesity, and improve glycemic control in type 2 diabetes (T2D).
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