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TREATMENT OUTCOMES OF GESTATIONAL TROPHOBLASTIC DISEASE, EXPERIENCE FROM SAUDI ARABIA.
J Ayub Med Coll Abbottabad
November 2024
Department of Medical Oncology, Prince Sultan Military Medical City, Riyadh-Saudi Arabia.
Background: This research aims to assess the treatment outcomes and chemotherapy duration required for the normalization of Human chorionic gonadotropin (HCG) levels in patients diagnosed with Gestational Trophoblastic Neoplasia (GTN), encompassing both benign and malignant forms of the condition.
Methods: This retrospective study included GTD patients treated with chemotherapy in a single oncology clinic from January 2016 to May 2022. Clinical data were gathered from electronic records of the patients.
Article Synopsis
- Prophylaxis strategies for Graft versus Host Disease (GVHD) in allogeneic hematopoietic cell transplantation (allo-HCT) often include a calcineurin inhibitor (CNI) combined with either methotrexate (MTX) or mycophenolate mofetil (MMF).
- A study analyzing data from 13,699 patients revealed that MTX-based prophylaxis was linked to lower overall mortality and non-relapse mortality compared to MMF, while showing no significant impact on relapse rates or relapse-free survival.
- Overall, MTX in combination with CNI was associated with better survival outcomes and a lower risk of severe acute GVHD compared to MMF.
Determination of multiple analytes in urine using label-free SERS coupled with simple sample pretreatments.
Anal Chim Acta
December 2024
Institute of Chemistry, Saratov State University, Astrakhanskaya 83, 410012, Saratov, Russia. Electronic address:
Article Synopsis
- The study focuses on improving label-free surface-enhanced Raman spectroscopy (SERS) by developing simple pretreatment steps to enhance the detection of target analytes in complex samples, such as urine, while minimizing interference from other substances.!* -
- Researchers successfully created a SERS assay that accurately detects three analytes—methotrexate, cephalosporin antibiotics, and creatinine—demonstrating effective monitoring of cancer treatment and kidney function in patients.!* -
- The findings emphasize the need to consider competitive adsorption on SERS surfaces in future assay developments, highlighting its critical role in achieving accurate and reliable analysis of body fluids.!*
Non-corticosteroid immunosuppressive medications for steroid-sensitive nephrotic syndrome in children.
Cochrane Database Syst Rev
November 2024
Cochrane Kidney and Transplant, Centre for Kidney Research, The Children's Hospital at Westmead, Westmead, Australia.
Background: About 80% of children with steroid-sensitive nephrotic syndrome (SSNS) have relapses. Of these children, half will relapse frequently, and are at risk of adverse effects from corticosteroids. While non-corticosteroid immunosuppressive medications prolong periods of remission, they have significant potential adverse effects.
View Article and Find Full Text PDFComparison of safety profile in patients with atopic dermatitis treated with dupilumab or conventional systemic treatment: real world data from the US network.
J Dermatolog Treat
December 2024
Institute and Comprehensive Center for Inflammation Medicine, University-Hospital Lübeck, Lübeck, Germany.
Article Synopsis
- The study analyzed the long-term safety of dupilumab, a drug for atopic dermatitis (AD), compared to conventional systemic treatments like azathioprine and methotrexate using electronic health records.
- Findings showed that dupilumab had a lower risk of various adverse effects, including infections and type 2 inflammatory diseases, compared to other treatments.
- However, the risk of conjunctivitis was higher in patients treated with dupilumab compared to those on mycophenolate mofetil and methotrexate, prompting the need for further research to confirm these results.
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