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Transcriptomic comparison of in vitro models of the human placenta.
bioRxiv
June 2024
Center for Developmental Biology and Regenerative Medicine, Seattle Children!s Research Institute, Seattle, WA 98101 United States.
Studying the human placenta through in vitro cell culture methods is necessary due to limited access and amenability of human placental tissue to certain experimental methods as well as distinct anatomical and physiological differences between animal and human placentas. Selecting an in vitro culture model of the human placenta is challenging due to representation of different trophoblast cell types with distinct biological roles and limited comparative studies that define key characteristics of these models. Therefore, the aim of this research was to create a comprehensive transcriptomic comparison of common in vitro models of the human placenta compared to bulk placental tissue from the CANDLE and GAPPS cohorts (N=1083).
View Article and Find Full Text PDFIdentification of equine mares as reservoir hosts for pathogenic species of .
Front Vet Sci
May 2024
National Centers for Animal Health Leptospira Working Group, U.S. Department of Agriculture, Ames, IA, United States.
Equine leptospirosis can result in abortion, stillbirth, neonatal death, placentitis, and uveitis. Horses can also act as subclinical reservoir hosts of infection, which are characterized as asymptomatic carriers that persistently excrete leptospires and transmit disease. In this study, PCR and culture were used to assess urinary shedding of pathogenic from 37 asymptomatic mares.
View Article and Find Full Text PDFHyperparathyroidism Jaw Tumor Syndrome, an Unforeseen Diagnosis.
JCEM Case Rep
March 2024
Department of Medicine, Division of Endocrinology, Stellenbosch University and Tygerberg Hospital, Cape Town 7505, South Africa.
Asymptomatic primary hyperparathyroidism (PHPT) is often missed in developing nations due to limited formal healthcare exposure and biochemical screening programs. Many patients are thus only diagnosed once symptomatic. We present a 32-year-old female who developed bony protrusions in her jaw during pregnancy, resulting in a stillbirth.
View Article and Find Full Text PDFThe interplay between toxoplasmosis and host miRNAs: Mechanisms and consequences.
Pathol Res Pract
October 2023
Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo 11231, Egypt; Biochemistry Department, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt.
Toxoplasmosis is one of the highly prevalent zoonotic diseases worldwide caused by the parasite Toxoplasma gondii (T. gondii). The infection with T.
View Article and Find Full Text PDFPrevalence of Toxoplasma gondii-like oocyst shedding in feral and owned cats in Damascus, Syria.
J Vet Intern Med
June 2023
Department of Microbiology and Biochemistry, Faculty of Pharmacy, Arab International University (AIU), Ghabagheb, Syria.
Background: The incidence of toxoplasmosis in humans in Syria indicates an increase in the number of infections with this disease. Cats are the only definitive host of Toxoplasma gondii and excrete environmentally resistant oocysts in their feces.
Objectives: Estimate the prevalence of T.
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