Succinate dehydrogenase activity in the odontogenic tissues of the hairless mouse (hr/hr) has been studied from the initiation of the dental lamina through apposition. Enzyme activities were designated as negative, slight, moderate and strong as a function of intensity of the reaction product. Enzyme levels in the odontogenic tissues increased with advancing tooth morphogenesis. Greatest activity was observed in the ameloblastic layer which peaked on the fourth to sixth postnatal days. This cell layer displayed higher enzyme activity than the ectomesenchymally-derived odontoblasts. Succinate dehydrogenase activity appeared to be related to the degree of differentiation and functional competence on the odontogenic tissues of the hairless mouse.
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