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J Vet Pharmacol Ther
August 1995
State Institute for Quality Control of Agricultural Products, Department of Toxicology, Wageningen, The Netherlands.
The pharmacokinetics of two sulfonamide/trimethoprim combinations were investigated after intravenous administration to clinically healthy pigs and to the same pigs following a challenge with Actinobacillus pleuropneumoniae toxins. Endobronchial challenge with A. pleuropneumoniae toxins resulted in fever, increased white blood cell counts and decreased water and feed consumption.
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