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Computational identification of monkeypox virus epitopes to generate a novel vaccine antigen against Mpox.
Biologicals
November 2024
Ege University Faculty of Science, Department of Biology, Molecular Biology Section, İzmir, Turkiye; Ege University Institute of Health Sciences, Department of Vaccine Studies, İzmir, Turkiye; Ege University Vaccine Development Application and Research Center, İzmir, Turkiye.
Monkeypox virus (MPXV) belonging to poxviridae family causes chronic viral disease in various mammals including human and monkeys. Conventional vaccines developed against smallpox of poxviridae, are not specific against Mpox. Also, they can cause various side effects after vaccination.
View Article and Find Full Text PDFDesigning a novel multi-epitope antigen for diagnosing human cytomegalovirus infection: An immunoinformatics approach.
Biotechnol Appl Biochem
October 2024
Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Shiraz, Iran.
Article Synopsis
- Human cytomegalovirus (HCMV) can cause severe health issues, especially in those with weakened immune systems, and current diagnostic tests for HCMV have limitations in sensitivity and specificity.
- Researchers aimed to create a new, more accurate multi-epitope antigen for diagnosing HCMV infections using immunoinformatic methods, selecting five key proteins based on their antigenic properties.
- The designed antigen showed promising stability and antigenicity without cross-reactivity and is a potential candidate for better HCMV diagnosis, although further lab testing is needed to confirm its effectiveness.*
Classification of Laboratory Test Outcomes for Maintenance Hemodialysis Patients Using Cellular Bioelectrical Measurements.
Int J Gen Med
August 2024
Department of Nephrology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, Jiangsu, 214000, People's Republic of China.
Background: End-stage kidney disease (ESKD) patients often face complications like anemia, malnutrition, and cardiovascular issues. Serological tests, which are uncomfortable and not frequently conducted, assist in medical assessments. A non-invasive, convenient method for determining these test results would be beneficial for monitoring patient health.
View Article and Find Full Text PDFDesign and expression of a chimeric recombinant antigen (SsIR-Ss1a) for the serodiagnosis of human strongyloidiasis: Evaluation of performance, sensitivity, and specificity.
PLoS Negl Trop Dis
July 2024
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
Background: The sensitivity of parasitological and molecular methods is unsatisfactory for the diagnosis of strongyloidiasis, and serological techniques are remaining as the most effective diagnostic approach. The present study aimed to design and produce a chimeric recombinant antigen from Strongyloides stercoralis immunoreactive antigen (SsIR) and Ss1a antigens, using immune-informatics approaches, and evaluated its diagnostic performance in an ELISA system for the diagnosis of human strongyloidiasis.
Methodology/principal Findings: The coding sequences for SsIR and Ss1a were selected from GenBank and were gene-optimized.
Structure of the type 38 Streptococcus pneumoniae capsular polysaccharide.
Carbohydr Res
July 2024
GSK, Siena, Italy. Electronic address:
Streptococcus pneumoniae is one of the globally important encapsulated human pathogens and more than 100 different serotypes have been identified. Despite very extensive genetic and immune-serological studies, the capsular polysaccharide repeating unit structure of several serotypes has not been determined yet, including the type 38 (type 38 in Danish nomenclature; type 71 in US nomenclature). Physicochemical data revealed that type 38 polysaccharide is composed of a pentasaccharide repeat unit →3)-[β-D-Galf(1 → 2)]-β-D-GalpA6(L-Ser)-(1 → 3)-α-D-GlcpNAc-(1 → 3)-α-D-Sugp-(1 → 4)-α-D-Galp(2OAc)-(1 → .
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