Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1021/ja01054a045 | DOI Listing |
Adv Sci (Weinh)
December 2024
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.
Antifungal resistance, particularly the rise of multidrug-resistance strains, poses a significant public health threat. In this study, the study identifies a novel multidrug-resistance gene, msp-8, encoding a helicase, through experimental evolution with Neurospora crassa as a model. Deletion of msp-8 conferred multidrug resistance in N.
View Article and Find Full Text PDFFront Plant Sci
November 2024
Department of Biology, University of Haripur, Haripur, Khyber Pakhtunkhwa, Pakistan.
is a plant-pathogenic fungus and a responsible agent for causing peach leaf curl disease. affects peach fruit production and contributes to global economic losses. Commercial fungicides may provide temporary relief; however, their overuse resulted in adverse environmental consequences as well as led to drug-resistant strains of .
View Article and Find Full Text PDFEur J Med Chem
December 2024
School of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, PR China. Electronic address:
A novel spiro [pyrrolidine-3',3'-quinoline]-2,2'-dione scaffold was constructed using fragments of quinoline and pyrrolidine. Subsequently, two series of derivatives were designed based on this scaffold. The enzyme inhibition experiments revealed that all designed compounds had moderate to good inhibitory activity against chitin synthase (CHS).
View Article and Find Full Text PDFEcotoxicol Environ Saf
November 2023
Key Laboratory of Agro-product Quality and Safety, Institute of Quality Standards & Testing Technology for Agro-products, Chinese Academy of Agricultural Sciences, Beijing, China. Electronic address:
Hidden ingredients in plant protection products (PPPs) threaten public health, food trade, and the environment. In this study, we developed a high-throughput screening method of 639 hidden ingredients in PPPs using GC-MS/MS in multiple reaction monitoring mode. Results showed that the qualitative criteria of retention time (t) shift and uncertainty of qualifier to quantifier ratio in the commercially available Shimadzu Smart Pesticides Database were set at < 0.
View Article and Find Full Text PDFInt J Mol Sci
September 2023
College of Agriculture, Guizhou University, Guiyang 550025, China.
Potato Verticillium wilt, caused by , is a serious soil-borne vascular disease, which restricts the sustainable development of the potato industry, and the pathogenic mechanism of the fungus is complex. Therefore, it is of great significance to explore the important pathogenic factors of to expand the understanding of its pathology. () gene is located in the Ca signaling pathway, which is highly conserved in filamentous fungi and involved in the regulation of a variety of biological processes.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!