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Cholestasis due to biliary obstruction can cause cardiogenic shock with bradycardia by delaying the elimination of arotinolol.
BMJ Case Rep
January 2025
Critical Care Medicine, Metropolitan Bokutoh Hospital, Tokyo, Japan.
Cardiogenic shock with bradycardia due to beta-blockers is well-documented; however, this condition in association with arotinolol is unreported. We present a case of cardiogenic shock resulting from delayed arotinolol clearance caused by bile duct obstruction. A man in his 60s presented to our hospital with jaundice.
View Article and Find Full Text PDFIsoproterenol mechanisms in inducing myocardial fibrosis and its application as an experimental model for the evaluation of therapeutic potential of phytochemicals and pharmaceuticals.
Animal Model Exp Med
December 2024
Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates.
Cardiac injury initiates repair mechanisms and results in cardiac remodeling and fibrosis, which appears to be a leading cause of cardiovascular diseases. Cardiac fibrosis is characterized by the accumulation of extracellular matrix proteins, mainly collagen in the cardiac interstitium. Many experimental studies have demonstrated that fibrotic injury in the heart is reversible; therefore, it is vital to understand different molecular mechanisms that are involved in the initiation, progression, and resolution of cardiac fibrosis to enable the development of antifibrotic agents.
View Article and Find Full Text PDFBeta-adrenergic blockade via atenolol negatively affects body and heart mass and renal morphology in the developing chicken (Gallus Gallus Domesticus).
Comp Biochem Physiol C Toxicol Pharmacol
November 2024
Developmental Integrative Biology Group, The University of North Texas, 1155 Union Circle, Denton, TX 76203, USA. Electronic address:
Atenolol is a widely prescribed β-cardioselective blocker. We studied atenolol effects on cardiac and renal development in day 18 (D18) chicken embryos. Embryos were dosed with atenolol (3 μg atenolol/g estimated embryo mass) for three days during one of the mesonephric kidney stage (D7-D9), mesonephric-metanephric stage (D11-D13), or metanephric stage (D15-D17), and then sampled on D18.
View Article and Find Full Text PDFIrisin Treatment Prevents Isoproterenol-Induced Cardiac Fibrosis in Mice.
Discov Med
November 2024
Department of Precision and Regenerative Medicine and Ionian Area - DiMePRe-J, University of Bari "Aldo Moro", 70124 Bari, Italy.
Background: Cardiac fibrosis is a pathophysiological process that occurs as the end stage of cardiovascular diseases. Irisin is a myokine secreted mainly by skeletal muscle exerting pleiotropic effects. Previous studies found altered irisin levels in patients with cardiovascular diseases and irisin has been shown to preserve cardiac function after ischemia-reperfusion injury in mice.
View Article and Find Full Text PDFEffects and mechanisms of dexmedetomidine preconditioning on isoproterenol-induced ventricular arrhythmias.
Sci Rep
November 2024
Department of Anesthesiology, Ya 'an People's Hospital, Ya 'an, 625000, Sichuan, China.
Article Synopsis
- - Dexmedetomidine (DEX) is known for its sedative and anti-anxiety properties, and it shows promise in preventing and treating arrhythmias during surgery, although its exact mechanisms are still not fully understood.
- - In experiments with mice, DEX was found to reduce the occurrence of ventricular arrhythmias induced by a stressor (isoproterenol or ISO) by stabilizing key cardiac electrical properties like action potential duration and calcium transient duration.
- - DEX pretreatment improved cardiac conduction and decreased variability in calcium signaling, indicating that it helps maintain calcium homeostasis and could be beneficial in preventing stress-induced heart issues.
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