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Chapter 4: Differential diagnosis of primary hyperparathyroidism.

Ann Endocrinol (Paris)

January 2025

Service d'endocrinologie, diabétologie, métabolisme, nutrition, hôpital Huriez, CHU de Lille, 1, rue Polonovski, 59037 Lille cedex, France; Inserm U1190, institut génomique européen pour le diabète, université de Lille, 59000 Lille, France. Electronic address:

The differential diagnosis of primary hyperparathyroidism can be considered clinically, biologically and radiologically. Clinically, primary hyperparathyroidism should be suspected in case of diffuse pain, renal lithiasis, osteoporosis, repeated fracture, cognitive or psychiatric disorder, or disturbance of consciousness. Nevertheless, the differential diagnosis of primary hyperparathyroidism is mainly biological, particularly in atypical forms, which must be differentiated from hypercalcemia with hypocalciuria or non-elevated PTH on the one hand, and from normo-calcemia with elevated PTH, hypophosphatemia or hypercalciuria on the other.

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[An unusual case of transient loss of consciousness: the Fahr's syndrome].

Recenti Prog Med

February 2008

Dipartimento di Clinica Medica, Immunologia e Malattie Infettive, Sezione di Medicina Interna, Università, Policlinico, Bari.

A 69-year-old male was admitted to our Division because of repeated episodes of transient loss of consciousness and minimal cognitive and behavioural disturbances. Brain CT showed Fahr-type bilateral calcifications. Laboratory findings showed a phospho-calcium metabolism disorder consistent with the diagnosis of pseudohypoparathyroidism, whose correction led to a significant clinical improvement.

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