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Special Collection: Drug Discovery in France Targeting Tumor-Associated Carbonic Anhydrases in Photothermal Therapy.
ChemMedChem
January 2025
Université de Montpellier, IBMM UMR 5247 - Pôle Chimie Balard Recherche, 1919 Route de Mende, 34293, Montpellier, FRANCE.
Tumor-associated human carbonic anhydrases (hCAs), particularly isoforms hCA IX and hCA XII, are overexpressed in hypoxic regions of solid tumors and play a crucial role in regulating pH homeostasis, promoting cancer cell survival and enhancing invasiveness. These enzymes have emerged as promising therapeutic targets in cancer treatment, including photothermal therapy (PTT). PTT is a minimally invasive technique that uses light-absorbing agents to convert near-infrared (NIR) light into heat, effectively inducing localized hyperthermia and promoting cancer cell apoptosis.
View Article and Find Full Text PDFEffectivity and safety profile of tenapanor, a sodium-hydrogen exchanger isoform 3 inhibitor, as an innovative treatment for hyperphosphatemia in chronic kidney disease: A systematic review of clinical studies.
Nefrologia (Engl Ed)
December 2024
Department of Medical Doctor Study Program, Faculty of Medicine, Hasanuddin University, Makassar City, South Sulawesi Province, Indonesia.
Background: Chronic kidney disease (CKD) is a major global health problem. Hyperphosphatemia is frequent in CKD and a reason for increased morbidity and mortality as it generates hyperparathyroidism, high fibroblast growth factor 23 (FGF23), and hypocalcemia. Available hyperphosphatemia therapies still have limitations, including risk of metal overload, cardiovascular calcification, and systemic adverse effects (AEs).
View Article and Find Full Text PDFSpatial and temporal distribution and ecological risk assessment of typical antibiotics in natural and wastewater of Jinjiang River Basin.
PLoS One
November 2024
School of Geological Engineering, Institute of Disaster Prevention, Sanhe, China.
Antibiotics are widely used in human medical, livestock, and aquaculture fields. Most antibiotics are water-soluble and cannot be fully absorbed by humans or animals. If feces or wastewater containing antibiotics are improperly treated or discharged directly into surface water or groundwater, it will undoubtedly have an impact on aquatic organisms.
View Article and Find Full Text PDFRemoval of persistent and mobile organic micropollutants from drinking water utilizing a synthesized waste-derived adsorbent.
Chemosphere
October 2024
German Environment Agency (UBA), Section II 3.3, Schichauweg 58, 12307 Berlin, Germany; Chair of Water Treatment, Technische Universität Berlin, Sekr. KF4, Straße des 17. Juni 135, 10623 Berlin, Germany.
Article Synopsis
- Persistent and mobile (PM) substances are harmful organic micropollutants that can linger and move through water, but current removal methods for these substances from drinking water are limited.
- This study introduced a new adsorbent made from used coffee grounds and aluminum waste, which effectively removed 25 organic micropollutants, including 22 PM substances, with some being completely eliminated from drinking water.
- Various characterization techniques confirmed the adsorbent's effectiveness, and a significant correlation was found between the decrease in UV light absorbance and the removal of these pollutants, suggesting that UV measurements can be a quick way to gauge removal efficiency.
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