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Defeating Melanoma Through a Nano-Enabled Revision of Hypoxic and Immunosuppressive Tumor Microenvironment.
Int J Nanomedicine
July 2023
Key Laboratory of Marine Drugs of Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong Province, People's Republic of China.
Rationale: Reversing the hypoxic and immunosuppressive tumor microenvironment (TME) is crucial for treating malignant melanoma. Seeking a robust platform for the effective reversion of hypoxic and immunosuppressive TME may be an excellent solution to revolutionizing the current landscape of malignant melanoma treatment. Here, we demonstrated a transdermal and intravenous dual-administration paradigm.
View Article and Find Full Text PDFGas exchange and dive behaviour in the diving beetle Platynectes decempunctatus (Coleoptera: Dytiscidae).
J Insect Physiol
October 2021
Department of Ecology and Evolutionary Biology, School of Biological Sciences, University of Adelaide, Adelaide, South Australia 5005, Australia.
Many aquatic insects use bubbles on the body surface to store and supply O for their dives. There are two types of bubbles: air stores, which store O gained from air at the surface, and gas gills that allow passive extraction of O from water. Many insects using air stores and gas gills return to the surface to replenish their bubbles and, therefore, their requirement for O influences dive behaviour.
View Article and Find Full Text PDFExtreme hypoxia and high lactate concentrations in early chicken embryos show that cutaneous oxygen uptake is limited by diffusion and metabolism is partially anaerobic.
J Comp Physiol B
November 2021
School of Biological Sciences, University of Adelaide, Adelaide, South Australia, 5005, Australia.
Respiratory gas exchange in avian embryos progresses through three stages inside the egg. During the first 3-5 days of incubation, the chicken embryo has no specialised respiratory organs and is not reliant on blood circulation. At this stage, it obtains oxygen mainly by diffusion through the eggshell, albumen, amniotic fluid and embryonic tissues.
View Article and Find Full Text PDFDoes hypoxia-inducible factor 1α play a role in regulating cutaneous oxygen flux in larval zebrafish (Danio rerio)?
J Comp Physiol B
July 2021
Department of Biology, University of Ottawa, Gendron Hall, 30 Marie Curie Private, Ottawa, ON, K1N 6N5, Canada.
Previous studies have demonstrated that hypoxia tolerance is improved in zebrafish (Danio rerio) larvae after prior exposure to lowered ambient O levels. Such improved hypoxia performance was attributed in part, to increased levels of hypoxia-inducible factor 1α (Hif-1α) exerting downstream effects on various physiological processes including promotion of trunk skin angiogenesis. Since O uptake ([Formula: see text]) in larvae is facilitated largely by O diffusion across the skin, enhanced cutaneous vascularization is expected to enhance [Formula: see text] during hypoxia and thus contribute to improved hypoxia tolerance.
View Article and Find Full Text PDFNeuropeptide Substance P Enhances Skin Wound Healing In Vitro and In Vivo under Hypoxia.
Biomedicines
February 2021
Department of Biomedical Engineering, Rutgers, State University of New Jersey, 599 Taylor Road, Piscataway, NJ 08854, USA.
Pressure ulcers (PUs) or sores are a secondary complication of diabetic neuropathy and traumatic spinal cord injury (SCI). PUs tend to occur in soft tissues located around bony prominences and may heal slowly or not at all. A common mechanism underlying impaired healing of PUs may be dysfunction of the local neurovascular system including deficiency of essential neuropeptides, such as substance P (SP).
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