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Unlabelled: Human REXO4 is a poorly characterized exonuclease that is overexpressed in human cancers. To better understand the function of REXO4 and its relationship to cellular proliferation, we have undertaken multidisciplinary approaches to characterize its cell cycle phase-dependent subcellular localization and the cis determinants required for this localization, its importance to cell cycle progression and cell viability, its protein-protein association network, and its activity. We show that the localization of REXO4 to the nucleolus in interphase depends on an N-terminal nucleolar localization sequence and that its localization to the perichromosomal layer of mitotic chromosomes is dependent on Ki67.
View Article and Find Full Text PDFRBIS regulates ribosome biogenesis to affect progression in lung adenocarcinoma.
J Transl Med
December 2024
Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Background: Increased ribosome biogenesis is required for tumor growth. In this study, we investigated the function and underlying molecular mechanism of ribosome biogenesis factor (RBIS) in the progression of non-small cell lung cancer (NSCLC).
Methods: In our study, we conducted a comprehensive analysis to identify key genes implicated in ribosome biogenesis by leveraging a Gene Set Enrichment Analysis (GSEA) dataset.
Ambient fine particulate matter provokes multiple modalities of cell death via perturbation of subcellular structures.
Environ Int
January 2025
Key Laboratory of Environmental Medicine Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing, Jiangsu 210009, China; Department of Toxicology, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China. Electronic address:
Fine particulate matter (PM2.5) is increasingly recognized for its detrimental effects on human health, with substantial evidence linking exposure to various forms of cell death and dysfunction across multiple organ systems. This review examines key cell death mechanisms triggered by PM2.
View Article and Find Full Text PDFMyosotis scorpioides L. (Boraginaceae) floral nectary: Micromorphology, fluorescence, and ultrastructure.
Micron
December 2024
Department of Botany and Plant Physiology, University of Life Sciences in Lublin, Akademicka 15, Lublin 20-950, Poland. Electronic address:
The small flowers of Myosotis scorpioides are pollinated by various groups of insects feeding on their nectar accumulating at the base of the corolla tube. To date, only few studies have focused on the anatomy and ultrastructure of nectaries in plants from the family Boraginaceae. The aim of this study was to analyse the structure of the M.
View Article and Find Full Text PDFTavWA1 is critical for wheat growth by modulating cell morphology and arrangement.
J Integr Plant Biol
January 2025
Key Laboratory of Seed Innovation, Institute of Genetics and Developmental Biology, The Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing, 100101, China.
Plant growth is determined by the production of cells and initiation of new organs. Exploring genes that control cell number and cell size is of great significance for understanding plant growth regulation. In this study, we characterized two wheat mutants, ah and dl, with abnormal growth.
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