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Curr Res Toxicol
December 2024
Large Molecule Analytical Development, Janssen Biologics LLC (a Johnson and Johnson Company), 200 Great Valley Parkway, Malvern, PA 19355 USA.
The present study describes the "fit for purpose" testing and the independent product-specific GMP validation of the monocyte activation test (MAT) to detect pyrogenic and pro-inflammatory contaminants, MAT Method A, Quantitative Test (European Pharmacopoeia, Ph. Eur. chapter 2.
View Article and Find Full Text PDFEcotoxicol Environ Saf
January 2025
Division of Toxicology, Institute for Medical Research and Occupational Health, Zagreb 10000, Croatia.
Measurements of polycyclic aromatic hydrocarbons (PAHs) were simultaneously carried out at three different urban locations in Croatia (Zagreb, Slavonski Brod and Vinkovci) characterized as urban residential (UR), urban industrial (UI) and urban background (UB), respectively. This was done in order to determine seasonal and spatial variations, estimate dominant pollution sources for each area and estimate the lifetime carcinogenic health risks from atmospheric PAHs. Mass concentrations of PAHs showed seasonal variation with the highest values during the colder period and the lowest concentration during the warmer period of the year.
View Article and Find Full Text PDFPlants (Basel)
December 2024
Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
spp. are soil-borne pathogens that cause damping-off and root rot diseases in many plant species such as cucumber. In the current study, the effect of dried roots-stems and leaves of (Sprengel) R.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Pre-Clinical Research Centre, Wrocław Medical University, Marcinkowskiego 1, 50-368 Wrocław, Poland.
Percutaneous Coronary Intervention (PCI) is a treatment method that involves reopening narrowed arteries with a balloon catheter that delivers a cylindrical, mesh-shaped implant device to the site of the stenosis. Currently, by applying a coating to a bare metal stent (BMS) surface to improve biocompatibility, the main risks after PCI, such as restenosis and thrombosis, are reduced while maintaining the basic requirements for the mechanical behavior of the stent itself. In this work, for the first time, the development and optimization process of the spatial structure of the Co-Cr stent (L-605) with a graphene-based coating using cold-wall chemical vapor deposition (CW-CVD) to ensure uniform coverage of the implant was attempted.
View Article and Find Full Text PDFJ Antimicrob Chemother
December 2024
Department of Medical Laboratory Science, I-Shou University, Kaohsiung City, Taiwan.
Objectives: Group A Streptococcus (GAS) results in invasive diseases. Our published studies show that AR-12 can directly kill GAS. However, AR-12 is toxic to the human microvascular endothelial cells (HMEC-1 cells) even at its MIC.
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