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Formononetin inhibits IgE by huPlasma/PBMCs and mast cells/basophil activation via JAK/STAT/PI3-Akt pathways.
Front Immunol
September 2024
Department of Pathology Microbiology & Immunology, New York Medical College, New York, NY, United States.
Article Synopsis
- Food allergies affect nearly 30 million people in the U.S., and managing them primarily involves avoiding allergens due to limited treatment options; this study explores the small molecule compound formononetin as a potential therapeutic alternative.* -
- The study findings reveal that formononetin significantly reduces IgE production and prevents mast cell degranulation in laboratory tests, indicating its potential effectiveness in treating food allergies.* -
- Formononetin impacts multiple targets related to food allergies and other diseases, and pathway analyses suggest it might influence processes involving B cell proliferation, primary immunodeficiency, and cancer pathways.*
Carrier-free nanoparticles based on self-assembly of 5-FU and copper-genistein complexes for the combined treatment of hepatocellular carcinoma.
Drug Deliv Transl Res
April 2025
Institute of Pharmacy & Pharmacology, University of South China, Hengyang, Hunan, China.
5-Fluorouracil (5-FU) is commonly used as a chemotherapeutic drug for advanced HCC. However, the effectiveness of 5-FU is limited by the emergence of resistance and poor targeting efficiency. Combining 5-FU with natural compounds has shown promise in HCC treatment.
View Article and Find Full Text PDFDevelopment and characterisation of highly specific monoclonal antibody-based immunoassays for the detection and quantification of genistein-7-O-[α-rhamnopyranosyl-(1→6)]-β-glucopyranoside in Derris scandens (Roxb.) Benth.
Phytochem Anal
April 2024
Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, Thailand.
Introduction: The stem of the plant species Derris scandens (Roxb.) Benth. (DS) contains genistein-7-O-[α-rhamnopyranosyl-(1→6)]-β-glucopyranoside (GTG), which is a unique marker.
View Article and Find Full Text PDFEffects of quercetin and genistein on egg quality, lipid profiles, and immunity in laying hens.
J Sci Food Agric
January 2024
College of Animal Science and Technology, State Key Laboratory of Animal Nutrition and Feeding, China Agricultural University, Beijing, China.
Background: After the peak laying stage, laying hens become susceptible to lipid accumulation and inflammatory reactions. The objective of this experiment was to examine the impact of quercetin and genistein on egg quality and lipid profiles in laying hens. A total of 240 Hy-Line Brown hens were randomly assigned to three dietary treatments.
View Article and Find Full Text PDFFormononetin Inhibits Mast Cell Degranulation to Ameliorate Compound 48/80-Induced Pseudoallergic Reactions.
Molecules
July 2023
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen University, No. 1066 Xueyuan Road, Nanshan District, Shenzhen 518055, China.
Formononetin (FNT) is a plant-derived isoflavone natural product with anti-inflammatory, antioxidant, and anti-allergic properties. We showed previously that FNT inhibits immunoglobulin E (IgE)-dependent mast cell (MC) activation, but the effect of FNT on IgE-independent MC activation is yet unknown. Our aim was to investigate the effects and possible mechanisms of action of FNT on IgE-independent MC activation and pseudoallergic inflammation.
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