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Accuracy of ESAT6-CFP10 skin test compared with tuberculin skin test in a healthy population: a randomized, blind, parallel controlled phase III clinical study.
BMC Infect Dis
December 2024
Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu Province, PR China.
Background: This study aimed to evaluate the diagnostic performance of ESAT6-CFP10 (EC) skin test in healthy population and determine the factors influencing the booster effect.
Methods: We conducted a randomized, double-blind, parallel controlled trial in healthy population. The experiment was divided into two stages.
Mycobacterium tuberculosis infection and tuberculosis disease in the first decade of life: a South African birth cohort study.
Lancet Child Adolesc Health
December 2024
Department of Epidemiology, School of Public Health, Boston University, Boston, MA, USA.
Background: Paediatric tuberculosis leads to more than 200 000 deaths annually. We aimed to investigate the incidence of Mycobacterium tuberculosis infection and tuberculosis disease in the first decade of life in the Drakenstein Child Health Study (DCHS), a South African cohort in a community with high tuberculosis and HIV incidence.
Methods: In this prospective birth cohort study, we enrolled pregnant women aged 18 years or older who were between 20 and 28 weeks' of gestation in a peri-urban setting outside of Cape Town, South Africa.
Clinical analysis of 20 cases of perinatal tuberculosis.
BMC Infect Dis
October 2024
Second Department of Infectious Disease, Kunming Children's Hospital, Kunming, 650000, Yunnan, China.
Background: To analyze the clinical manifestations, diagnostic and therapeutic processes of perinatal tuberculosis in children, providing reference for clinicians in the diagnosis and treatment of this disease.
Methods: A retrospective analysis was conducted on the epidemiological history, clinical manifestations, laboratory and imaging findings, and treatment follow-up of 20 cases of perinatal tuberculosis diagnosed in the Second Department of Infectious Disease, Kunming Children's Hospital, from February 2014 to September 2021.
Results: Of the 20 cases, 13 were male (65.
Natural outbreak of infection in imported laboratory cynomolgus macaques (): diagnostic pitfalls and management of safety precautions.
J Toxicol Pathol
October 2024
AnaPath Services GmbH, Hammerstrasse 49, 4410 Liestal, Switzerland.
Article Synopsis
- Tuberculosis (TB) poses a significant health risk to both humans and non-human primates used in research, especially given the challenges posed by emerging mycobacterial species.
- A natural outbreak of TB was found in imported cynomolgus macaques at AnaPath Research S.A.U. after initial negative tests, leading to extensive screening and diagnosis of the affected animals.
- Despite most macaques showing no symptoms, necropsies confirmed TB in 10 out of 114 animals, tracing the infection back to Asia, while all sanitary measures taken successfully eradicated the disease.
Ocular tuberculosis associated with Epstein-Barr virus myelitis: A case report.
Infect Med (Beijing)
September 2024
Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, 14359-44711, Iran.
Ocular tuberculosis (OTB) is a chronic eye infection caused by . Some cases of myelitis are associated with (EBV), with 1-5% of EBV infections leading to neurologic complications. We describe a 34-year-old Iranian woman with OTB and EBV coinfection.
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