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Recent Prospectives of Cellular Signaling Role for Mammary Gland Carcinogenesis.
Anticancer Agents Med Chem
January 2025
Department of Pharmaceutical Sciences, Lucknow University, Lucknow, UP, India.
In women globally, breast cancer ranks as the second most frequent cause of cancer-related deaths, making up about 25% of female cancer cases, which is pretty standard in affluent countries. Breast cancer is divided into subtypes based on aggressive, genetic and stage. The precise cause of the problem is still unknown.
View Article and Find Full Text PDFCharacterization of a Hypothetical Protein (PBJ89160.1) from Exhibits a New Insight on Nutritional Virulence and Molecular Docking to Uncover a Therapeutic Target.
Evol Bioinform Online
November 2024
Department of Biotechnology and Genetic Engineering, Noakhali Science and Technology University, Noakhali, Bangladesh.
Article Synopsis
- The study aims to enhance understanding of the bacterial meningitis-causing diplococcus by identifying a functional protein that could be targeted for future treatments.
- Using a hypothetical protein (HP), researchers employed various bioinformatics methods and homology modeling to predict the protein's structure and function.
- Results indicated that HP is acidic and soluble, is localized in the periplasm, and Loperamide shows the best potential as a therapeutic agent by inhibiting the protein's transporter activity.
Acanthamoeba castellanii trophozoites need oxygen for normal functioning and lipids are their preferred substrate, offering new possibilities for treatment.
Int J Parasitol
January 2025
Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center, Rotterdam, the Netherlands. Electronic address:
Acanthamoebae, pathogenic free-living amoebae, can cause Granulomatous Amoebic Encephalitis (GAE) and keratitis, and for both types of infection, no adequate treatment options are available. As the metabolism of pathogens is an attractive treatment target, we set out to examine the energy metabolism of Acanthamoeba castellanii and studied the aerobic and anaerobic capacities of the trophozoites. Under anaerobic conditions, or in the presence of inhibitors of the electron-transport chain, A.
View Article and Find Full Text PDFIn silico study of some plant compounds as potential anticancer agents targeting MALT1 allosteric domain.
J Biomol Struct Dyn
September 2024
Department of Biochemistry, Federal University of Technology, Akure, Ondo State, Nigeria.
Article Synopsis
- MALT1 is a crucial protein involved in immune responses, and its unusual signaling is linked to various diseases, including cancer, making it a target for new therapies.
- The study aimed to identify plant-based small molecules that could bind to MALT1 using computational methods, screening 34 compounds for their effectiveness.
- Cyanidin emerged as a promising allosteric inhibitor of MALT1, showing better binding and stability than the control drug thioridazine, but further testing is necessary to confirm its effectiveness in treating cancer and related diseases.
Novel regimens of phytopolyphenols and celecoxib enhancing efficacy and selectivity of anticancer effects of chemotherapeutic agents on cultured cancer cells.
J Dent Sci
July 2024
School of Dentistry, College of Oral Medicine, Chung Shan Medical University, Taichung, Taiwan.
Background/purpose: Explorations of novel regimens enhancing efficacy and selectivity of chemotherapeutic agents are urgent to solve the problems of cancer therapy. This study aimed to explore synergistic anticancer effects of novel regimens of phytopolyphenols [curcumin (C), tea polyphenols (G) or GC] with celecoxib (Cl) and ZnSO.
Materials And Methods: Antiproliferative effects of drugs on cultured cancer cells and pathogenic biofilms were assayed by MTT and optical density (OD600) respectively; their inhibition on efflux pump (Na-K-ATPase) was measured by colorimetric methods.
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