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Structured Polymers Enable the Sustained Delivery of Glucocorticoids within the Intra-Articular Space.
Adv Healthc Mater
December 2024
Dept of Biomedical Sciences. Institute of Clinical Sciences, University of Birmingham, Birmingham, UK.
Intra-articular glucocorticoid injections are effective in controlling inflammation and pain in arthritides but restricted by short duration of action and risk of joint degeneration. Controlled drug release using biocompatible hydrogels offers a unique solution, but limitations of in situ gelation restrict their application. Gellan sheared hydrogels (GSHs) retain the advantages of hydrogels, however their unique microstructures lend themselves to intra-articular application - capable of shear thinning under force but restructuring at rest to enhance residence.
View Article and Find Full Text PDFAssessing the Efficacy of Arthrocentesis in Managing Temporomandibular Joint Disorders and Internal Derangements: A Case Series.
Cureus
August 2024
Department of Oral and Maxillofacial Surgery, Guru Nanak Dev Dental College & Research Institute, Sunam, IND.
Internal joint derangements (IJD) of the temporomandibular joint (TMJ) encompass a multifaceted array of conditions that have the potential to induce a gradual decline in joint health, ultimately resulting in persistent pain and disruptions in daily living. The management of these conditions poses significant hurdles to achieving effective pain management and restoration of normal TMJ functionality, presenting ongoing challenges in the medical field. At present, the approach of utilizing arthrocentesis in conjunction with intra-articular injections containing corticosteroids (CSs) and hyaluronic acid (HA) is a commonly employed method aimed at addressing chronic pain, surpassing the outcomes of more conservative treatment modalities.
View Article and Find Full Text PDFThe Effectiveness of Alpha-2-Macroglobulin Injections for Osteoarthritis of the Knee.
Bull Hosp Jt Dis (2013)
December 2024
Background: Intra-articular (IA) injections of plateletrich plasma (PRP) have been increasingly used in the nonoperative treatment of knee osteoarthritis (OA) but have considerable heterogeneity in both formulation and clinical results. Alpha-2-macroglobulin (A2M) is a large plasma protein found in PRP that inhibits cartilage-degrading enzymes and could be an efficacious OA treatment independently. The purpose of this study was to compare the short-term clinical efficacy of IA injection of A2M-rich PRP concentrate to conventionally prepared PRP and corticosteroids in the management of symptomatic knee OA.
View Article and Find Full Text PDFLessons From Delayed Intradermal Testing: A Case of Fixed Drug Eruption From Intra-Articular Methylprednisolone.
J Allergy Clin Immunol Pract
August 2024
Division of Allergy & Immunology, Department of Medicine, Montefiore Medical Center, Bronx, NY. Electronic address:
Development of hyaluronic acid hydrogel containing prednisolone-encapsulated nonphospholipid liposomes for the treatment of rheumatoid arthritis.
J Biomed Mater Res B Appl Biomater
August 2024
Department of Chemical Engineering, National Taiwan University, Taipei, Taiwan.
Rheumatoid arthritis (RA) requires therapeutic approaches that alleviate symptoms and inhibit the progression of joint damage. Glucocorticoids (GCs) have been a cornerstone of RA treatment, yet their use is often limited by side effects. Recent advancements suggest that liposome-based delivery systems can improve GC biodistribution, minimizing toxicity.
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