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X-ray irradiation effectively inactivated lymphocytes in transfusion in vivo monitored by the bioluminescence transfusion-associated graft-versus-host disease model.
Vox Sang
March 2024
Institute of Health Service and Transfusion Medicine, Beijing, People's Republic of China.
Background And Objectives: Transfusion of cold-stored whole blood is the preferred resuscitation method for trauma patients but may cause transfusion-associated graft-versus-host disease (TA-GVHD). Standard clinical practice to prevent this is to irradiate blood components with gamma-rays. X-ray irradiations are also a safe and effective alternative to gamma-ray irradiation.
View Article and Find Full Text PDFCellular kinetics of hematopoietic cells with deletion are present at different frequencies in bone-marrow and spleen in X-irradiated mice.
Int J Radiat Biol
September 2020
Laboratory of Environmental Health Science, Oita University of Nursing and Health Sciences, Oita City, Japan.
Purpose: Several past studies using a mouse model of radiation-induced AML (rAML) have shown that hemizygous deletion of the Sfpi1 gene (HDSG) is an initiating event for the development of rAML. In this study, we examined the difference in frequency of HDSG in hematopoietic stem cells (HSCs) Rich hematopoietic Cell population (HRCs) from bone marrow (BM) and spleen of C3H mice irradiated with 3 Gy X-rays.
Materials And Methods: 8-weeks old male C3H mice were irradiated 3Gy of whole body X-ray (1 Gy/min) and mice were sacrificed at 1, 4, 8, and 26 weeks.
Effects of the mutation on X-ray-induced deletions in the brain and spleen of delta mice.
Genes Environ
May 2020
Division of Genetics and Mutagenesis, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki-shi, Kanagawa 210-9501 Japan.
Background: DNA-dependent protein kinase (DNA-PK), consisting of a Ku heterodimer (Ku70/80) and a large catalytic subunit (DNA-PKcs), plays an important role in the repair of DNA double-strand breaks via non-homologous end-joining (NHEJ) in mammalian cells. Severe combined immunodeficient () mice carry a mutation in the gene encoding DNA-PKcs and are sensitive to ionizing radiation. To examine the roles of DNA-PKcs in the generation of deletion mutations in vivo, we crossed mice with delta transgenic mice for detecting mutations.
View Article and Find Full Text PDFIKK Inhibitor IMD-0354 Attenuates Radiation Damage in Whole-body X-Irradiated Mice.
Oxid Med Cell Longev
June 2020
Department of Radiation Sciences, Hirosaki University Graduate School of Health Sciences, 66-1 Hon-cho, Hirosaki, Aomori 036-8564, Japan.
Nuclear factor-kappa B (NF-B) transcription factor plays a critical role in regulating radiation-induced inflammatory and immune responses. Intracellular reactive oxygen species generation induces the activation of NF-B via the inhibitor of B (IB) kinase (IKK) complex signaling. Previous studies have reported that the inhibition of IKK-driven NF-B activation offers a therapeutic strategy for managing inflammatory disorders and various cancers, but it has additionally been reported that treatment targeting NF-B also shows a radioprotective effect.
View Article and Find Full Text PDFCandidate protein markers for radiation biodosimetry in the hematopoietically humanized mouse model.
Sci Rep
September 2018
Center for Radiological Research, Columbia University Medical Center, New York, NY, 10032, USA.
After a radiological incident, there is an urgent need for fast and reliable bioassays to identify radiation-exposed individuals within the first week post exposure. This study aimed to identify candidate radiation-responsive protein biomarkers in human lymphocytes in vivo using humanized NOD scid gamma (Hu-NSG) mouse model. Three days after X-irradiation (0-2 Gy, 88 cGy/min), human CD45+ lymphocytes were collected from the Hu-NSG mouse spleen and quantitative changes in the proteome of the human lymphocytes were analysed by mass spectrometry.
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