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Impact of Species and Tissue Differences on In Vitro Glucuronidation of Diclofenac.
Molecules
December 2024
Department of Pharmaceutical Science, College of Pharmacy and Health Sciences, Texas Southern University, 3100 Cleburne Street, Houston, TX 77004, USA.
Background: The aim of this study is to determine the impact of species and tissue differences on the glucuronidation of diclofenac in vitro.
Method: Microsomes from different species (rat, monkey, mouse, dog, and human) and rat and human tissues (liver, intestine, and kidney) were used to assess the rate of glucuronidation reaction of diclofenac. The metabolites were quantified using ultra high-performance liquid chromatography (UHPLC) and fitted into a Michaelis-Menten model to determine the metabolic kinetic parameters.
Italian Guidelines for the diagnosis and treatment of Fetal Alcohol Spectrum Disorders: detecting alcohol drinking during pregnancy.
Riv Psichiatr
October 2024
Institute of Biochemistry and Cell Biology (IBBC-CNR), Department of Sensory Organs, Sapienza University of Rome, Italy.
Article Synopsis
- - Fetal Alcohol Spectrum Disorders (FASD) refers to a variety of conditions caused by drinking alcohol during pregnancy, impacting the central nervous system, growth, and facial features.
- - Early screening for FASD is critical since there are no treatments; methods include assessing alcohol biomarkers in maternal blood and meconium, as well as using sensitive questionnaires to identify at-risk pregnancies.
- - The review emphasizes the importance of combining alcohol biomarkers with traditional screening tools to ensure more accurate detection and monitoring of alcohol consumption during pregnancy.
The development of rapid immunoassays for the urinary analysis of 1-hydroxypyrene glucuronide facilitate both laboratory and on-site polycyclic aromatic hydrocarbon biomonitoring.
Toxicol Lett
November 2024
RAPIvD Ltd, Sharnbrook, United Kingdom.
Polycylic Aromatic Hydrocarbons (PAHs) are produced during the incomplete burning of organic materials. PAH sources include vehicle exhaust, tobacco smoke and waste incineration. Environmental and occupational exposures to PAHs are known to occur.
View Article and Find Full Text PDFAlcohol Use among Young Women in Kampala City: Comparing Self-Reported Survey Data with Presence of Urinary Ethyl Glucuronide Metabolite.
Int J Environ Res Public Health
September 2024
Uganda Youth Development Link, P.O. Box 12659 Kampala, Uganda.
This study sought to determine the level of concordance between self-reported alcohol use and the presence of its urinary ethyl glucuronide (EtG) metabolite in women living in urban Kampala. In 2023, we recruited 300 young women, ages 18 to 24 years, to participate in a prospective cohort study across three sites in urban Kampala (i.e.
View Article and Find Full Text PDFChemical Isotope Labeling and Dual-Filtering Strategy for Comprehensive Profiling of Urinary Glucuronide Conjugates.
Anal Chem
August 2024
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa Macao SAR, China.
Glucuronidation, a crucial process in phase II metabolism, plays a vital role in the detoxification and elimination of endogenous substances and xenobiotics. A comprehensive and confident profiling of glucuronate-conjugated metabolites is imperative to understanding their roles in physiological and pathological processes. In this study, a chemical isotope labeling and dual-filtering strategy was developed for global profiling of glucuronide metabolites in biological samples.
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