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Arginase-1-specific T cells target and modulate tumor-associated macrophages.
J Immunother Cancer
January 2025
National Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Herlev Hospital, Herlev, Denmark
Background: Arginase-1 (Arg1) expressing tumor-associated macrophages (TAMs) may create an immune-suppressive tumor microenvironment (TME), which is a significant challenge for cancer immunotherapy. We previously reported the existence of Arg1-specific memory T cells among peripheral blood mononuclear cells (PBMCs) and described that Arg-1-based immune modulatory vaccines (IMVs) control tumor growth and alter the M1/M2 macrophage ratio in murine models of cancer. In the present study, we investigated how Arg1-specific T cells can directly target TAMs and influence their polarization.
View Article and Find Full Text PDFA Behavioral Screening Method for Predicting PTSD-like Phenotypes: Novel Application to Female Rats.
J Neurosci Methods
January 2025
Dept. of Physiology and Pharmacology, Sapienza University of Rome, 00185 Rome, Italy; Neuropharmacology Unit, IRCCS Santa Lucia Foundation, 00143 Rome, Italy. Electronic address:
Background: Only a small percentage of trauma-exposed subjects develop PTSD, with females being twice as likely. Most rodent models focus on males and fail to account for inter-individual variability in females.
New Method: We tested a behavioral PTSD model in female rats to distinguish between susceptible and resilient individuals.
Collegiate Male Athlete Attitudes Toward Male and Female Strength and Conditioning Coaches.
J Strength Cond Res
February 2025
Department of Wellness and Movement Sciences, Eastern Washington University, Cheney, Washington.
Taylor, K, and Little, SJ. Collegiate male athlete attitudes toward male and female strength and conditioning coaches. J Strength Cond Res 39(2): 277-280, 2025-Sports have long been male dominated, but there have been recent increases in the involvement of women in athletic administration and athlete support, that is, strength and conditioning.
View Article and Find Full Text PDFCryopreserved Umbilical Cord Mesenchymal Stem Cells Show Comparable Effects to Un-Cryopreserved Cells in Treating Osteoarthritis.
Cell Transplant
January 2025
School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Non-cryo and hypothermic preservations are two available options for short-term storage of living cells. For long-term cell storage, cryopreservation is an essential procedure as it prolongs the storage time, allowing for the transport and testing of cells, as well as the establishment of cell banks. But it is unclear whether cryopreservation reduces the therapeutic effects of human umbilical cord mesenchymal stem cells (hucMSCs) on osteoarthritis (OA).
View Article and Find Full Text PDFOptimized human dedifferentiated fat cells from the buccal fat pad-derived osteoinductive extracellular vesicles promote osteoblast differentiation.
J Dent Sci
January 2025
Second Department of Oral and Maxillofacial Surgery, Osaka Dental University, Osaka, Japan.
Background/purpose: Bone reconstruction in the maxillofacial region typically relies on autologous bone grafting, which presents challenges, including donor site complications and graft limitations. Recent advances in tissue engineering have identified highly pure and proliferative dedifferentiated fat cells (DFATs) as promising alternatives. Herein, we explored the capacity for osteoblast differentiation and the osteoinductive characteristics of extracellular vesicles derived from DFATs (DFAT-EVs).
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