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A proposed framework of strategies to overcome challenges to surgical quality assurance in oncology trials (SQA-Onc.).
Eur J Surg Oncol
January 2025
Imperial College London, Department of Surgery and Cancer, Block B Hammersmith Hospital, London, W12 0HS, UK. Electronic address:
Introduction: Randomised controlled trials (RCTs) with surgical interventions frequently lack a framework to ensure surgical quality. We aimed to investigate surgical quality assurance (SQA) in oesophagogastric oncology trials and to develop a translatable framework of strategies to overcome challenges in the design and implementation of SQA.
Methods: Seventy-one peer-nominated, international, expert trial stakeholders included surgeons; oncologists; trial managers and trial methodologists.
Hypothalamic deep brain stimulation augments walking after spinal cord injury.
Nat Med
December 2024
Defitech Center for Interventional Neurotherapies (.NeuroRestore), CHUV/UNIL/EPFL, Lausanne, Switzerland.
A spinal cord injury (SCI) disrupts the neuronal projections from the brain to the region of the spinal cord that produces walking, leading to various degrees of paralysis. Here, we aimed to identify brain regions that steer the recovery of walking after incomplete SCI and that could be targeted to augment this recovery. To uncover these regions, we constructed a space-time brain-wide atlas of transcriptionally active and spinal cord-projecting neurons underlying the recovery of walking after incomplete SCI.
View Article and Find Full Text PDFUtilising a modified accelerated Delphi process to develop a national multidisciplinary consensus on peri-operative optimisation of patients with obesity undergoing non-bariatric surgery.
Surgeon
October 2024
Department of Colorectal Surgery, University of Limerick Hospital Group, Limerick, Ireland.
Article Synopsis
- * Through three rounds of electronic surveys among a multidisciplinary team, 94 consensus statements were established focusing on pre-operative, intra-operative, and post-operative care.
- * Key recommendations included prehabilitation and risk stratification before surgery, careful surgical approaches during the procedure, and comprehensive post-operative care that includes pain management and physiotherapy support.
Large-scale exome array summary statistics resources for glycemic traits to aid effector gene prioritization.
Wellcome Open Res
October 2023
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Article Synopsis
- Genome-wide association studies have found numerous genetic loci linked to glycemic traits, but connecting these loci to specific genes and biological pathways remains a challenge.
- Researchers conducted meta-analyses of exome-array studies across four glycemic traits, analyzing data from over 144,000 participants, which led to the identification of coding variant associations in more than 60 genes.
- The study revealed significant pathways related to insulin secretion, zinc transport, and fatty acid metabolism, enhancing understanding of glycemic regulation and making data available for further research.
Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Outcomes and Endpoints.
Neurocrit Care
October 2024
Departments of Critical Care Medicine, Neurology, and Neurosurgery, UPMC Healthcare System, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Background: Clinical management of persons with disorders of consciousness (DoC) is dedicated largely to optimizing recovery. However, selecting a measure to evaluate the extent of recovery is challenging because few measures are designed to precisely assess the full range of potential outcomes, from prolonged DoC to return of preinjury functioning. Measures that are designed specifically to assess persons with DoC are often performance-based and only validated for in-person use.
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