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Exploration of Novel Metabolic Features Reflecting Statin Sensitivity in Lung Cancer Cells.
Biol Pharm Bull
December 2024
Department of Veterinary Anatomy, School of Veterinary Medicine, Tottori University.
Article Synopsis
- Statins are drugs that lower cholesterol and have anti-cancer effects by inhibiting a key enzyme in cholesterol production.
- Research shows that the effectiveness of statins varies in different cancer cells, potentially linked to the presence of E-cadherin, which may act as a marker for statin sensitivity.
- Comparing gene expressions and metabolite levels in lung cancer cell lines revealed that statin-sensitive cells have lower cholesterol synthesis gene expression and reduced levels of related metabolites, indicating that these cells might have a limited capacity for cholesterol production and storage when treated with atorvastatin.
Expression and characterization of pantothenate energy-coupling factor transporters as an anti-infective drug target.
Protein Sci
November 2024
Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Department of Drug Design and Optimization, Saarbrücken, Germany.
This study investigates the potential of energy-coupling factor (ECF) transporters as promising anti-infective targets to combat antimicrobial resistance (AMR). ECF transporters, a subclass of ATP-binding cassette (ABC) transporters, facilitate the uptake of B-vitamins across bacterial membranes by utilizing ATP as an energy source. Vitamins are essential cofactors for bacterial metabolism and growth, and they can either be synthesized de novo or absorbed from the environment.
View Article and Find Full Text PDFMechanistic in vitro study of the effect of Cucurbita moschata (Cucurbitaceae) on carbohydrate digestive enzymes.
J Food Sci
December 2024
Faculty of Chemical Engineering, Autonomous University of Yucatán, Mérida, Yucatán, Mexico.
Diabetes is marked by postprandial hyperglycemia (PHG), an abnormal rise in blood glucose after meals. A key therapeutic goal to reduce PHG is the inhibition of α-amylase (αAM) and α-glucosidase (αGL), enzymes that break down carbohydrates into sugars. Cucurbita moschata has been shown to inhibit both enzymes.
View Article and Find Full Text PDFNINJ1 regulates ferroptosis via xCT antiporter interaction and CoA modulation.
Cell Death Dis
October 2024
Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, 27710, USA.
Ninjurin-1 (NINJ1), initially identified as a stress-induced protein in neurons, recently emerged as a key mediator of plasma membrane rupture (PMR) during apoptosis, necrosis, and pyroptosis. However, its involvement in ferroptosis is less well elucidated. Here, we demonstrate that NINJ1 also plays a crucial role in ferroptosis, but through a distinct mechanism.
View Article and Find Full Text PDFChemical synthesis and enzymatic late-stage diversification of novel pantothenate analogues with antiplasmodial activity.
Eur J Med Chem
December 2024
Department of Chemistry, McGill University, Montreal, Quebec, Canada, H3A 0B8. Electronic address:
Article Synopsis
- The rise of resistance in malaria-causing Plasmodium parasites highlights the urgent need for new treatments, as current antimalarials are becoming less effective.
- Researchers have developed a new series of pantothenamide analogues that replace a vulnerable chemical group with an isoxazole ring, enhancing their stability and biological activity.
- Thirteen new compounds showed strong anti-Plasmodium activity and low toxicity to human cells, demonstrating the potential of late-stage diversification to create effective and safer antimalarials.
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