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Nuclear factor I-C regulates intramembranous bone formation via control of FGF signalling.
Heliyon
January 2025
Department of Oral Histology-Developmental Biology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea.
Our previous studies indicate that NFI-C is essential for tooth root development and endochondral ossification. However, its exact role in calvarial intramembranous bone formation remains unclear. In this study, we demonstrate that the disruption of the gene leads to defects in intramembranous bone formation, characterized by decreased osteogenic proliferative activity and reduced osteoblast differentiation during postnatal osteogenesis.
View Article and Find Full Text PDFMicroiontophoretic Application of Dynorphin in Dental Pain: Excitatory or Inhibitory Effects.
J Pain Res
January 2025
Department of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, Korea.
Background: The tooth exhibits increased sensitivity to noxious stimuli due to the dense innervation of thin myelinated Aδ fibers and unmyelinated C fibers within the dental pulp. While prior research has identified dynorphin expression in layers I-II of the dorsal horn across the spinal cord in various pain models, its functional role in trigeminal nociception, including tooth pain, remains underexplored. This study examines the potential role of dynorphin in the nociceptive processing of dental stimuli.
View Article and Find Full Text PDFUlcerative Lesions in the Intertriginous Areas of an Adolescent Female Patient: A Case of Inverse Erosive Lichen Planus.
Cureus
December 2024
Dermatology, All India Institute of Medical Sciences, Rishikesh, Rishikesh, IND.
Lichen planus is a common mucocutaneous disorder that can affect various parts of the body, with its erosive variant typically involving the oral mucosa. This variant rarely affects the skin, and even less commonly, the flexural regions. Here, we present a case of a 14-year-old girl who presented with ulcerated, itchy lesions in the intertriginous areas for one year.
View Article and Find Full Text PDFComparative evaluation of calretinin immunohistochemical expression in calcifying odontogenic cyst and ameloblastoma.
BMC Oral Health
January 2025
Oral Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Background: Calretinin is a 29 kilodalton (KDa) calcium-binding protein that is expressed in normal and tumoral tissues. The expression of calretinin has been shown in the dental epithelium during odontogenesis and in different odontogenic cysts and tumors such as ameloblastoma. Since the epithelium of calcifying odontogenic cyst (COC) is similar to ameloblastoma and in both lesions, an arrangement of loose cells similar to stellate reticulum is seen, we aimed to investigate the comparative expression of calretinin in COC and ameloblastoma.
View Article and Find Full Text PDFFrom Flare to Care: Pancreas Primer for Everyone.
Gastroenterol Clin North Am
March 2025
Division of Gastroenterology, Hepatology and Nutrition, University of Minnesota, 420 Delaware Street SE, MMC 36, Minneapolis, MN 55455, USA. Electronic address:
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