Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Microviridae bacteriophages influence behavioural hallmarks of food addiction via tryptophan and tyrosine signalling pathways.
Nat Metab
November 2024
Department of Diabetes, Endocrinology and Nutrition, Dr Josep Trueta University Hospital, Girona, Spain.
Food addiction contributes to the obesity pandemic, but the connection between how the gut microbiome is linked to food addiction remains largely unclear. Here we show that Microviridae bacteriophages, particularly Gokushovirus WZ-2015a, are associated with food addiction and obesity across multiple human cohorts. Further analyses reveal that food addiction and Gokushovirus are linked to serotonin and dopamine metabolism.
View Article and Find Full Text PDFMelanin-like nanoparticles slow cyst growth in ADPKD by dual inhibition of oxidative stress and CREB.
EMBO Mol Med
November 2024
The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), State Key Laboratory of Experimental Hematology, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Article Synopsis
- Melanin-like nanoparticles (MNPs) are emerging as effective antioxidant therapy agents due to their biocompatibility and ability to scavenge reactive oxygen species (ROS), but research on their effects in chronic diseases is still limited.
- In this study, researchers created an ultra-small formulation called MMPP, which was shown to accumulate in renal tubules and significantly reduce oxidative stress and cyst growth in a model of autosomal dominant polycystic kidney disease (ADPKD).
- The mechanism behind MMPP's therapeutic potential involves its binding to the CREB protein, which inhibits gene expression related to cyst growth, thus providing a dual approach to treating oxidative stress and disease progression in ADPKD.
In addition to tumor imaging, advanced high-tech PET/CT imaging is increasingly used to elucidate the underlying causes of fever of unknown origin caused by various inflammatory processes, including pyelonephritis. Two clinical cases of whole-body PET/CT with 18F-FDG glucose, which allowed to visualize the molecular and cellular features of acute pyelonephritis as the cause of fever of unknown origin, are presented in the article. The scientifically based mechanisms of this process and the reliability of the results are discussed.
View Article and Find Full Text PDFArticle Synopsis
- The study analyzed global, regional, and national trends in injury burden and identified risk factors contributing to injuries using data from the GBD 2019.
- In 2019, there were approximately 713.9 million injury incidents and 4.3 million injury-related deaths globally, with low bone mineral density emerging as the leading risk factor.
- The findings emphasize the need for effective global injury prevention policies by highlighting the persistent impact of injuries on global health.
Long term outcomes of pituitary adenomas in Multiple Endocrine Neoplasia type 1: a nationwide study.
Front Endocrinol (Lausanne)
October 2024
Endocrinology & Nutrition Department, Hospital Universitario de Vall d´Hebron, Barcelona, Spain.
Article Synopsis
- MEN1-related pituitary adenomas (PAs) were traditionally thought to be more aggressive than regular pituitary adenomas, but recent research indicates that their behaviors may be similar.
- A study evaluated long-term outcomes of MEN1 PAs using data from 84 cases, focusing on factors like patient demographics, tumor size, and treatment effectiveness.
- The findings suggest that while MEN1 micro-PAs generally have a low risk of becoming invasive, microPRLomas have a higher risk, indicating that less frequent long-term monitoring may be suitable for patients with MEN1-related PAs.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!