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Amitriptyline and duloxetine attenuate activities of superficial dorsal horn neurons in a rat reserpine-induced fibromyalgia model.
J Pharmacol Sci
November 2024
Department of Physical Therapy, Faculty of Rehabilitation, Niigata University of Health and Welfare, Niigata, 950-3198, Japan; Institute for Human Movement and Medical Sciences (IHMMS), Niigata University of Health and Welfare, Niigata, 950-3198, Japan. Electronic address:
Fibromyalgia (FM) is an intractable disease with a chief complaint of chronic widespread pain. Amitriptyline (AMI) and duloxetine (DLX), which are antidepressant drugs, have been reported to ameliorate pain in patients with FM and pain-related behaviors in several rodent models of FM. However, the mechanisms of action of AMI and DLX are not yet fully understood.
View Article and Find Full Text PDFAntidepressant-like effects of Cimicifuga dahurica (Turcz.) Maxim. via modulation of monoamine regulatory pathways.
Physiol Behav
October 2024
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, Liaoning, China.
Sheng-ma is recorded in the Compendium of Materia Medica and mainly originates from the rhizomes of Cimicifuga dahurica (Turcz.) Maxim. (CD), Cimicifuga heracleifolia Kom.
View Article and Find Full Text PDFStructural insights into vesicular monoamine storage and drug interactions.
Nature
May 2024
Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, MO, USA.
Biogenic monoamines-vital transmitters orchestrating neurological, endocrinal and immunological functions-are stored in secretory vesicles by vesicular monoamine transporters (VMATs) for controlled quantal release. Harnessing proton antiport, VMATs enrich monoamines around 10,000-fold and sequester neurotoxicants to protect neurons. VMATs are targeted by an arsenal of therapeutic drugs and imaging agents to treat and monitor neurodegenerative disorders, hypertension and drug addiction.
View Article and Find Full Text PDFLigand recognition and G-protein coupling of trace amine receptor TAAR1.
Nature
December 2023
Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Trace-amine-associated receptors (TAARs), a group of biogenic amine receptors, have essential roles in neurological and metabolic homeostasis. They recognize diverse endogenous trace amines and subsequently activate a range of G-protein-subtype signalling pathways. Notably, TAAR1 has emerged as a promising therapeutic target for treating psychiatric disorders.
View Article and Find Full Text PDFThe monoaminergic pathways are involved in the antidepressant-like effect of quercetin.
Naunyn Schmiedebergs Arch Pharmacol
April 2024
Department of Pharmacology and Toxicology, College of Pharmacy, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria.
Quercetin, a plant-derived flavonoid, is an antioxidant and has demonstrated antidepressant and anti-inflammatory activities in several animal models. However, there is scanty information on the underlying mechanisms of its antidepressant property. This present study aimed at assessing the involvement of monoaminergic systems in the antidepressant-like activity of quercetin in experimental animals.
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