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Adaptive approach to diagnosis of amebic liver abscess in non-endemic areas.
Diagn Microbiol Infect Dis
January 2025
Division of Infectious Diseases, Naval Medical Center San Diego, 34800 Bob Wilson Drive, San Diego, CA, 92134, USA; Department of Medicine, Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD 20814, USA.
Entamoeba histolytica infections range from asymptomatic intestinal amebiasis to more severe syndromes like invasive colitis or hepatic abscess. While diagnostic tests available for assessing these infections have evolved, the optimal use of newer diagnostics like enteric multiplex Polymerase Chain Reaction (PCR) panels has not been fully established. Here we describe the case of a 34-year-old male with an amebic liver abscess (ALA) that was diagnosed via multiplex Gastrointestinal (GI) PCR panel on formed stool and subsequently confirmed by testing liver abscess fluid (off-label) on the same multiplex GI PCR panel leading to rapid diagnosis and targeted treatment modification with excellent outcome.
View Article and Find Full Text PDFA rare case of amebic liver abscess with spontaneous hepatico-cholecystic as well as cholecysto-duodenal fistula.
Med J Armed Forces India
December 2024
Senior Advisor (Medicine) & Gastroenterologist, Command Hospital, (Southern Command), Pune, India.
Autochthonous amebiasis in Spain.
Rev Esp Enferm Dig
November 2024
Gastroenterología y Hepatología, Hospital Universitario Fundación Jiménez Díaz.
Article Synopsis
- Amoebiasis is an infection caused by the protozoan Entamoeba histolytica, typically transmitted through the faecal-oral route and affecting the intestines and liver, especially in tropical areas.
- A case study details a 56-year-old Spanish man who presented with abdominal pain and fever, leading to imaging studies that revealed significant intestinal and liver abnormalities.
- Treatment involved ultrasound-guided drainage of a liver abscess and antibiotic therapy, resulting in a positive response.
Rapid Detection of Amoebic Liver Abscess Using Recombinase Polymerase Amplification Assay in Resource-Limited Settings.
Am J Trop Med Hyg
January 2025
Department of Medical Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Amoebic liver abscess (ALA) is a significant public health concern in tropical countries. Traditional diagnostic methods, such as microscopy, have low sensitivity, and nested polymerase chain reaction (nPCR) has lengthy turnaround times. In this study, we aimed to evaluate the effectiveness of the recombinase polymerase amplification (RPA) assay for detecting Entamoeba histolytica in amoebic liver pus samples.
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