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In an autopsied female primary polycythemia was definitely diagnosed only after histological examination. A classical form of Vaquez-Osler disease was characterized by pronounced normo-, granulo- and megakaryocyte hyperplasia of the bone marrow, spleen and liver myelosis with an admixture of atypical megakaryocytes and splenomegaly. There was a complication in the form of two coronary arteries thrombosis.

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Left ventricular performance has been studied in 50 patients affected by primary polycythemia (P.V.) by determining systolic time intervals.

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An example of chocked disk of 3-4 diopters (right eye) and 4-5 diopters (left eye) in a patient with cerebral alteration (encephalomalacia respectively bleeding) suffering from polycythemia vera is discussed in the light of own observation, literature, differential diagnosis, pathogenesis, and therapy. An internal treatment by radioactive phosphorus and blood-letting gave restitutio fere ad integrum.

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