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Biomarkers to aid in diagnosis of allergic contact dermatitis.
Front Allergy
February 2025
Department of Pathology, Microbiology, & Immunology, New York Medical College, Valhalla, NY, United States.
Allergic contact dermatitis (ACD) is an increasingly common skin condition characterized by itchy rashes in response to allergens. The most common diagnostic test involves patch testing (PT), but despite the efficacy of PT for identifying and guiding patients toward avoidance of allergens, PT alone does not elucidate the underlying biomechanistic changes which may be useful for sub-categorizing ACD further. In addition, some patients may never be able to identify their causative allergens unless they go to highly specialized ACD centers.
View Article and Find Full Text PDFLow-level neurostimulation of the renal nerves as a potential therapeutic strategy for hypertension treatment.
Front Pharmacol
February 2025
Division of Pulmonology, Allergy and Immunology, Department of Pediatrics, School of Medicine, Case Western Reserve University, Cleveland, OH, United States.
Background: Neurostimulation is an emerging treatment for conditions like hypertension. The renal nerves, comprising sensory afferent and sympathetic efferent fibers, are crucial for blood pressure (BP) regulation. The inhibitory reno-renal reflex, where central integration of renal sensory input reduces sympathetic outflow and systemic BP, presents a promising target for neurostimulation interventions.
View Article and Find Full Text PDFPotential Biomarkers Indicating Resistance or Resilience in Experimental Peri-Implant Mucositis: A Systematic Review and Meta-Analysis.
Clin Oral Implants Res
March 2025
Division of Periodontics, Department of Stomatology, School of Dentistry, University of São Paulo (USP), São Paulo, São Paulo, Brazil.
Objectives: To identify changes in immunological, microbiological, and histological biomarkers that may indicate resistance during the induction phase and resilience during the resolution phase of experimental peri-implant mucositis (PiM).
Materials And Methods: The search was performed in MEDLINE, EMBASE, Web of Science, SCOPUS, Cochrane Library, and LILACS databases. Prospective interventional studies assessing biomarkers during experimental PiM were included.
The Impact of Immunomodulatory Components Used in Clinical Nutrition-A Narrative Review.
Nutrients
February 2025
Department of Human Nutrition and Dietetics, Faculty of Food Technology, University of Agriculture in Krakow, al. Mickiewicza 21, 31-120 Krakow, Poland.
Background: Malnutrition is a clinical condition that leads to unfavourable changes in health. It affects 35-55% of hospitalized patients, and in the case of cancer, this prevalence rises to 40-90% of patients. Screening nutritional status is essential for preventing undernutrition, which is crucial as its treatment.
View Article and Find Full Text PDFTrastuzumab Decreases the Expression of G1/S Regulators and Syndecan-4 Proteoglycan in Human Rhabdomyosarcoma.
Int J Mol Sci
February 2025
Department of Biochemistry, Faculty of Medicine, University of Szeged, 6720 Szeged, Hungary.
Rhabdomyosarcoma (RMS), the most common soft tissue sarcoma in children, arises from skeletal muscle cells that fail to differentiate terminally. Two subgroups of RMS, fusion-positive and fusion-negative RMS (FPRMS and FNRMS, respectively), are characterized by the presence or absence of the fusion gene. RMSs frequently exhibit increased expression of human epidermal growth factor receptor-2 (HER2).
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