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Pregnane C21-Steroids with Anti-inflammatory Activity from the Roots of Cynanchum bungei.
Chem Biodivers
January 2025
Guangdong Medical University School of Pharmacy, School of Pharmacy, Xincheng Road, 523808, Dongguan, CHINA.
Article Synopsis
- Five new pregnane C21-steroids were identified from the roots of Cynanchum bungei, including three previously unknown 5,6-epoxy steroids and two 8,14-seco-steroids.
- Compound 3 is notable for being the first 5a,6a-epoxy steroid discovered in Cynanchum plants, with their structures confirmed through various spectroscopic methods and theoretical calculations.
- All isolated compounds showed anti-inflammatory properties by inhibiting nitric oxide release in RAW264.7 cells, with compounds 3 and 4 demonstrating stronger activity than the commonly used anti-inflammatory drug indomethacin at a concentration of 50 μM.
Integrated proteomics and metabolomics network analysis across different delivery modes in human pregnancy: a pilot study.
BMC Pregnancy Childbirth
December 2024
Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Background: Delivery mode has been linked to child health, e.g., allergic disease.
View Article and Find Full Text PDFComprehensive profiling and identification of C21 steroids in the root of Marsdenia tenacissima (Dai-Bai-Jie) using offline two-dimensional chromatography (LC × SFC) with Q-TOF/MS.
J Chromatogr A
January 2025
Beijing Institute of Radiation Medicine, Beijing, 100850, China; Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China. Electronic address:
Dai-Bai-Jie, the root of the plant Marsdenia tenacissima from the Asclepiadaceae family, is well-known for its therapeutic effects in clearing heat, detoxifying, reducing swelling, and relieving pain as one of the most commonly used Dai medicine. Due to numerous structurally similar C21 steroidal compounds in Dai-Bai-Jie, chemical composition profiling has been substantially challenged. In this study, an offline two-dimensional chromatographic method (LC × SFC separation system) was developed to address these issues.
View Article and Find Full Text PDFThree New Steroids from the Roots of Marsdenia tenacissima.
Chem Biodivers
December 2024
The MOE Key Laboratory of Standardization of Chinese Medicines and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica (ICMM), Shanghai University of Traditional Chinese Medicine (SHUTCM), Shanghai, 201203, PR China.
Three undescribed pregnane steroids, 12β-O-4-hydroxybenzoyl tenacigenin D (1), 12β-O-4-hydroxybenzoyl tenacigenin A (2), and 11α-nicotinoyl-17β-marsdenin (3), along with two known analogues (4 and 5), were isolated from the roots of Marsdenia tenacissima. Their structures were elucidated using one- and two-dimensional NMR, high-resolution electron ionization-mass spectrometry, single-crystal X-ray diffraction data, and experimental and density-functional-theory-calculated electronic circular dichroism measurements. All isolated compounds were evaluated for their cytotoxic activities against human lung cancer cells (A549), ovarian carcinoma cells (SKOV-3), gastric cancer cells (MGC 803) and breast cancer cells (MCF-7).
View Article and Find Full Text PDFComprehensive biomarker profiles and chemometric filtering of urinary metabolomics for effective discrimination of prostate carcinoma from benign hyperplasia.
Sci Rep
March 2022
Department of Chemistry, University of Turin, Via P. Giuria 7, 10125, Turin, Italy.
Prostate cancer (PCa) is the most commonly diagnosed cancer in male individuals, principally affecting men over 50 years old, and is the leading cause of cancer-related deaths. Actually, the measurement of prostate-specific antigen level in blood is affected by limited sensitivity and specificity and cannot discriminate PCa from benign prostatic hyperplasia patients (BPH). In the present paper, 20 urine samples from BPH patients and 20 from PCa patients were investigated to develop a metabolomics strategy useful to distinguish malignancy from benign hyperplasia.
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