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Cortical Neurotransmitters Measured by Magnetic Resonance Spectroscopy Change Following Traumatic Brachial Plexus Injury.
J Brachial Plex Peripher Nerve Inj
January 2025
School of Health Sciences, Manchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
GABA (γ-aminobutyric acid) is the major inhibitory neurotransmitter in the brain. In response to injury within the central nervous system, GABA promotes cortical plasticity and represents a potential pharmacological target to improve functional recovery. However, it is unclear how GABA changes in the brain after traumatic brachial plexus injuries (tBPIs) which represents the rationale for this pilot study.
View Article and Find Full Text PDFTranscirculation repair of a direct carotid-cavernous fistula in a patient who presented with hydrocephalus: illustrative case.
J Neurosurg Case Lessons
January 2025
The Trauma and Neuroscience Institutes, St. John's Hospital and Medical Center, Tulsa, Oklahoma.
Background: Direct carotid-cavernous fistulas (CCFs) are relatively rare but dangerous complications of penetrating traumatic brain injury or maxillofacial trauma. A variety of clinical signs have been described, including ophthalmological and neurological ones. In some cases, severely altered cerebral blood flow can present as massive life-threatening bleeding through the nose, subarachnoid hemorrhage, and/or intraparenchymal hemorrhage.
View Article and Find Full Text PDFDiagnostic Utility of Procalcitonin and Lactate Determination in Cerebrospinal Fluid for the Diagnosis of Neonatal Meningitis.
J Clin Med
January 2025
Department of Neonatal Diseases, University Clinical Hospital No. 2, Powstańców Wielkopolskich 72 Street, 70-111 Szczecin, Poland.
: The diagnosis of meningitis is based on microbiological analysis of the cerebrospinal fluid, and the evaluation of cytosis and biochemical parameters such as protein and glucose levels. Sometimes when there is a traumatic lumber puncture, the cerebrospinal fluid is bloody, which makes it difficult to diagnose. The objective of the study was to examine the performance of cerebrospinal fluid (CSF) procalcitonin (PCT) and lactate as potential markers for the diagnosis of meningitis in neonates.
View Article and Find Full Text PDFDevelopment and validation of a model to predict cognitive impairment in traumatic brain injury patients: a prospective observational study.
EClinicalMedicine
February 2025
Department of Rehabilitation Medicine, Third Affiliated Hospital of Soochow University, Changzhou, China.
Background: Traumatic brain injury (TBI) is a significant public health issue worldwide that affects millions of people every year. Cognitive impairment is one of the most common long-term consequences of TBI, seriously affect the quality of life. We aimed to develop and validate a predictive model for cognitive impairment in TBI patients, with the goal of early identification and support for those at risk of developing cognitive impairment at the time of hospital admission.
View Article and Find Full Text PDFPost-traumatic Acinetobacter baumannii Meningitis Following Penetrating Trauma: A Case Report.
Cureus
December 2024
Department of Critical Care Medicine, Chris Hani Baragwanath Academic Hospital, Johannesburg, ZAF.
This report details the case of a 29-year-old male patient who presented at a tertiary-level trauma centre with multiple stab wounds to the face, chest, and back. Despite not undergoing surgical intervention or exhibiting any apparent cerebrospinal fluid (CSF) leakage during the initial evaluation. The patient's condition deteriorated, with subsequent cultures from CSF and blood confirmed extensively drug-resistant (XDR) Acinetobacter baumannii (A.
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