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Non-invasive 4D transcranial functional ultrasound and ultrasound localization microscopy for multimodal imaging of neurovascular response.
Sci Rep
December 2024
Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, NC, 27599, USA.
A long-standing goal of neuroimaging is the non-invasive volumetric assessment of whole brain function and structure at high spatial and temporal resolutions. Functional ultrasound (fUS) and ultrasound localization microscopy (ULM) are rapidly emerging techniques that promise to bring advanced brain imaging and therapy to the clinic with the safety and low-cost advantages associated with ultrasound. fUS has been used to study cerebral hemodynamics at high temporal resolutions while ULM has been used to study cerebral microvascular structure at high spatial resolutions.
View Article and Find Full Text PDFRight to Left Shunt and Cryptogenic Stroke in Patients Over 60 Years Old.
Pril (Makedon Akad Nauk Umet Odd Med Nauki)
November 2024
Healthcare Center, Skopje, RN Macedonia.
Article Synopsis
- - This study investigates the connection between patent foramen ovale (PFO), a right to left shunt, and cryptogenic stroke in patients aged 60 and older, comparing it to known causes of stroke.
- - Researchers used contrast-enhanced bubble Transcranial Doppler ultrasonography to examine 172 patients (86 aged 60+) and found a higher prevalence of PFO in those with cryptogenic strokes versus those with known causes.
- - Results indicate that PFO is significantly associated with cryptogenic strokes in older patients, and the bubble-cTCD method is suggested as a reliable first-line detection technique for PFO in this age group.
Effect of insulin on indices of cerebral blood flow and cerebrovascular compliance in young adults.
Am J Physiol Heart Circ Physiol
January 2025
Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, United States.
Insulin has important vasodilatory effects in the peripheral circulation, but less is known about insulin's role in cerebrovascular control. Herein, we hypothesized both systemic (intravenous) and local (intranasal) insulin administration would increase indices of cerebral blood flow and reduce cerebrovascular compliance (Ci) in young adults. Participants were assigned to one of four separate protocols.
View Article and Find Full Text PDFA comprehensive benchmarking of a U-Net based model for midbrain auto-segmentation on transcranial sonography.
Comput Methods Programs Biomed
January 2025
Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region of China; Research Institute of Smart Ageing, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region of China. Electronic address:
Background And Objective: Transcranial sonography-based grading of Parkinson's Disease has gained increasing attention in recent years, and it is currently used for assistive differential diagnosis in some specialized centers. To this end, accurate midbrain segmentation is considered an important initial step. However, current practice is manual, time-consuming, and bias-prone due to the subjective nature.
View Article and Find Full Text PDFContinuous transcranial ultrasound in large vessel stroke: Image guidance for high-intensity focused sonothrombolysis.
J Neuroimaging
November 2024
Department of Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
Background And Purpose: Sonothrombolysis is a potential adjunctive therapy for large vessel occlusion (LVO) stroke. Bedside ultrasound image-guided high-intensity focused ultrasound (HIFU) therapy could deliver higher energy therapeutic ultrasound to the thrombus with higher precision than what was previously accomplished in human trials. The aim is to test the feasibility of diagnostic transcranial contrast-enhanced ultrasound (CEUS) to image the occlusion site and continuously maintain the guidance image on-target for a sufficient exposure time for HIFU to be effective during LVO stroke evaluation and treatment.
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