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Injectable Nanocomposite Hydrogels for Intervertebral Disc Degeneration: Combating Oxidative Stress, Mitochondrial Dysfunction, and Ferroptosis.
Adv Healthc Mater
March 2025
Department of Orthopaedics, Key Laboratory of Structural Malformations in Children of Zhejiang Province, Key Laboratory of Orthopaedics of Zhejiang Province, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
Intervertebral disc degeneration (IVDD) is a major cause of low back pain, where oxidative stress and mitochondrial dysfunction are key contributors. Additionally, ferroptosis, an iron-dependent form of cell death, is identified as a critical mechanism in IVDD pathogenesis. Herein, the therapeutic potential of gallic acid (GA)-derived PGA-Cu nanoparticles, enhanced with functional octapeptide (Cys-Lys-His-Gly-d-Arg-d-Tyr-Lys-Phe, SS08) to build the mitochondria-targeted nanoparticles (PGA-Cu@SS08), and embedded within a hydrogel matrix to form a nanocomposite hydrogel, is explored.
View Article and Find Full Text PDFSaving sheep - On extinction narratives in Namibian Swakara farming.
Camb Prism Extinct
March 2024
Faculty of Humanities and Social Sciences, Cultural and Social Anthropology, University of Bayreuth, Bayreuth, Germany.
The Namibian Swakara industry, a type of sheep farming focused on the production of lamb pelts for the fashion industry, currently faces a crisis situation. Formerly one of the most important export products from Namibia, a combination of drought, falling pelt prices and the effects of the COVID-19 pandemic now threaten the survival of Swakara, the Namibian Karakul. The current crisis is articulated in extinction narratives.
View Article and Find Full Text PDFGlobal, regional and national burden of decubitus ulcers in 204 countries and territories from 1990 to 2021: a systematic analysis based on the global burden of disease study 2021.
Front Public Health
March 2025
Department of Burns and Plastic Surgery, The 83 Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.
Background: Decubitus ulcers, also known as pressure ulcers, pose a significant public health challenge due to their substantial impact on morbidity, mortality, and healthcare expenditures.
Methods: The number and age-standardized rates (ASRs) of prevalence, death, disability adjusted life-year (DALY), years of life lost (YLL), and years lived with disability (YLD) at the global, regional, and national levels were acquired from the GBD 2021 database. Trends were evaluated based on the estimated average percentage change (EAPC) of ASRs.
Burden, risk factors, and projections of ischemic heart disease in China (1990-2021): findings from the 2021 GBD study.
Front Cardiovasc Med
February 2025
Department of Anesthesiology, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan, China.
Background: Ischemic heart disease (IHD) remains a major public health challenge in China. This study aimed to comprehensively analyze the burden of IHD, its risk factors, and future trends from 1990 to 2021 using the Global Burden of Disease database.
Methods: We assessed IHD trends in incidence, prevalence, mortality, and disability-adjusted life years (DALYs) stratified by age (greater than 15 years) and gender.
Post-stroke dysphagia: identifying the evidence missing.
Front Med (Lausanne)
February 2025
Atlantica Instituto Universitario, Gestao em Saude, Oeiras, Portugal.
Dysphagia is a high-profile dysfunction that often occurs after a stroke, with a prevalence of 50%-80%. Post-stroke dysphagia (PSD) often leads to serious complications such as pneumonia and malnutrition, reducing the quality of life and leading to poor prognosis or even death. PSD causes these adverse physical and psychological impairments to patients, which becomes a challenge for both patients and physicians.
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