Front Pediatr
February 2025
Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Rosai-Dorfman disease (RDD) is an unusual, non-malignant proliferative disorder involving non-Langerhans cell histiocytes, characterized by a wide range of clinical presentations and distinctive atypical morphological patterns. The concurrent manifestation of acute lymphoblastic leukemia (ALL) alongside RDD is exceptionally rare. Here, we present the case of a 14-year-old male patient diagnosed with ALL who, during the consolidation phase of chemotherapy, developed multifocal bone, dural, and liver lesions, as confirmed through CT and MRI imaging.
View Article and Find Full Text PDFFront Med (Lausanne)
February 2025
Center of Optometry, Department of Ophthalmology, Peking University People's Hospital, Institute of Ophthalmic and Optometric Medicine, Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Optometry School of Peking University Health Science Center, Beijing, China.
Objective: This study aimed to examine the clinical characteristics of choroidal metastases (CMs) and assess the efficacy of various treatment strategies for CMs in a specific patient cohort.
Methods: This retrospective case series study included 32 patients (38 eyes) diagnosed with CM at the Department of Ophthalmology, Peking University People's Hospital, between 2009 and 2022. The cohort included 10 male patients (10 eyes) and 22 female patients (28 eyes), with a mean age of 52.
The patient was a 51-year-old man who was diagnosed as having prostate cancer(adenocarcinoma)in December Year X-3. He underwent total prostatectomy in June Year X-2. The lesions were confined to the right lobe of the prostate.
View Article and Find Full Text PDFFront Vet Sci
February 2025
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, United States.
Background: Pulmonary involvement of Non-Langerhans Cell Histiocytosis (PNLCH) is a rare cause of interstitial pulmonary disease in people and are classified as either Erdheim-Chester disease (ECD) or Rosai-Dorfman disease (RDD). In veterinary medicine, feline pulmonary Langerhans cell histiocytosis (PLCH) has been identified as an infiltrative histiocytic disorder with an insidious onset of progressive respiratory distress and is non-responsiveness to empiric therapies. Unfortunately, subsequent death either from respiratory failure or humane euthanasia are the reported outcomes in all reported cases.
View Article and Find Full Text PDFClin Neurol Neurosurg
March 2025
Section of Neurosurgery, Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan; Center of Oncological Research in Surgery, Aga Khan University Hospital, Karachi, Pakistan. Electronic address:
Introduction: Multicentric and multifocal gliomas are rare and mainly described in high-grade gliomas, however, they have rarely been reported with LGG in about 2-10 % of all cases. This study aims to identify the reported multicentric low-grade gliomas (mLGGs) in literature and review their pathologies, management, and outcomes.
Methods: A systematic search using a pre-defined search strategy was conducted across three databases (PubMed, Cochrane Library, and Scopus).
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