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Does Frequent Use of Advanced Energy Devices Improve Hysterectomy Outcomes?
Medicina (Kaunas)
December 2024
Department of Obstetrics and Gynecology, Korea University College of Medicine, 73 Inchon-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.
: The objective of this study was to assess the efficient use of advanced energy devices by examining the impact of their usage frequency on surgical outcomes of total laparoscopic hysterectomies. : A retrospective study was conducted between 2020 and 2023 by a single surgeon. The patients' medical records and surgical videos were reviewed.
View Article and Find Full Text PDFEfficacy and safety of multi-target tyrosine kinase inhibitor AL2846 combined with gemcitabine in pancreatic cancer.
Invest New Drugs
January 2025
Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Key Laboratory of Digestive Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
Pancreatic cancer patients urgently need new treatments, and we explored the efficacy and safety of combination therapy with AL2846 and gemcitabine in pancreatic cancer patients. This was a single-arm, single-center, open-label phase I/IIa study (NCT06278493). The dose-escalation phase was designed to evaluate the maximum tolerated dose (MTD) of AL2846 combined with gemcitabine.
View Article and Find Full Text PDFIncreased gastrointestinal bleeding-related mortality during the COVID-19 pandemic.
Therap Adv Gastroenterol
January 2025
F. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, West Hollywood 90048, CA, USAKarsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Article Synopsis
- The study analyzes national data on gastrointestinal bleeding (GIB) mortality in the U.S. from 2010 to May 2023, highlighting trends and identifying vulnerable populations.
- Despite a consistent decrease in GIB deaths from 2010 to 2019, there was a surge in excess mortality during the COVID-19 pandemic, especially among young males aged 19-44.
- By 2023, GIB-related mortality rates returned to expected levels, indicating a resolution of pandemic-related excess deaths.
Reduction of bleeding by cabozantinib in metastatic renal cell carcinoma with hereditary hemorrhagic telangiectasia.
Int Cancer Conf J
January 2025
Department of Urology, Kobe University Graduate School of Medicine, 7-51 Kusunoki-cho, Kobe, Japan.
Hereditary hemorrhagic telangiectasia (HHT) is a rare genetic disorder characterized by refractory recurrent epistaxis and gastrointestinal bleeding. Recent studies have reported the hemostatic effects of tyrosine kinase inhibitors on HHT-related bleeding. A 67-year-old man with HHT underwent laparoscopic radical nephrectomy for right renal cell carcinoma discovered during an investigation of anemia.
View Article and Find Full Text PDFNavigating complex arterial reconstruction in living donor liver transplantation: the role of the splenic artery as a viable conduit.
BMC Surg
January 2025
Liver Transplant Unit, Gastrointestinal Surgical Center (GISC), Surgery Department, Mansoura University, Mansoura, Dakahleyya, Egypt.
Background: In living donor liver transplantation (LDLT), maintaining hepatic arterial flow is critical for graft survival. Alternative methods are required when the recipient's hepatic artery is unsuitable due to extensive dissection or inadequate flow. This study evaluates the efficacy and safety of splenic artery transposition (SAT) for hepatic arterial reconstruction in LDLT.
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