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Complementary cognitive roles for D2-MSNs and D1-MSNs during interval timing.
Elife
January 2025
Department of Neurology, University of Iowa, Iowa City, United States.
The role of striatal pathways in cognitive processing is unclear. We studied dorsomedial striatal cognitive processing during interval timing, an elementary cognitive task that requires mice to estimate intervals of several seconds and involves working memory for temporal rules as well as attention to the passage of time. We harnessed optogenetic tagging to record from striatal D2-dopamine receptor-expressing medium spiny neurons (D2-MSNs) in the indirect pathway and from D1-dopamine receptor-expressing MSNs (D1-MSNs) in the direct pathway.
View Article and Find Full Text PDFEditors' role in shaping the publishing environment and guiding authors in the era of artificial intelligence.
Croat Med J
December 2024
Hrvoje Barić, Croatian Medical Journal, Zagreb, Croatia,
Serum metabolome indicators of early childhood development in the Brazilian National Survey on Child Nutrition (ENANI-2019).
Elife
January 2025
Department of Social and Applied Nutrition, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
The role of circulating metabolites on child development is understudied. We investigated associations between children's serum metabolome and early childhood development (ECD). Untargeted metabolomics was performed on serum samples of 5,004 children aged 6-59 months, a subset of participants from the Brazilian National Survey on Child Nutrition (ENANI-2019).
View Article and Find Full Text PDFCurrent landscape and future prospects of interleukin-2 receptor (IL-2R) agonists in cancer immunotherapy.
Oncoimmunology
December 2025
Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.
Immune checkpoint blockade (ICB) has significantly improved the survival for many patients with advanced malignancy. However, fewer than 50% of patients benefit from ICB, highlighting the need for more effective immunotherapy options. High-dose interleukin-2 (HD IL-2) immunotherapy, which is approved for patients with metastatic melanoma and renal cell carcinoma, stimulates CD8 T cells and NK cells and can generate durable responses in a subset of patients.
View Article and Find Full Text PDF[Older patients with suspected malignancy].
Ned Tijdschr Geneeskd
January 2025
Amsterdam UMC, locatie VUmc, afd. Medische Oncologie en Interne Geneeskunde, Amsterdam.
Some older patients with suspected malignancy are not automatically eligible for a standard care process due to frailty or limited treatment wishes. For this group we recommend a personalized approach in which frailty is identified and the patient's wishes are central. To achieve appropriate care, cooperation and timely consultation between primary care or elderly care with a geriatric and/or oncological specialist from secondary care is important.
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