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Homologous In-Radiolabeled Platelet Survival and Sequestration Exploration for Refractory Immunologic Thrombocytopenic purpura in Children: A Strategy to Avoid Unnecessary Splenectomy.
Mol Imaging
January 2025
Nuclear Medicine Department, Montpellier University Hospital, University of Montpellier, Montpellier, France.
Immunologic thrombocytopenic purpura (ITP) is a condition that affects four to 18 per 100 000 children every year. In most cases, spontaneous remission occurs, but splenectomy may be proposed. Exploring the site of platelet sequestration can help to better predict potential poor responders to splenectomy, but In-radiolabeled platelet scintigraphy (IPS) can be difficult to perform in children with very few platelets.
View Article and Find Full Text PDFContrast-enhanced Ultrasound as a Method of Splenic Injury Assessment.
J Med Ultrasound
September 2024
Wroclaw Medical University, Wroclaw, Poland.
Splenic injuries are common in abdominal trauma, as the spleen is one of the most often harmed organs. The treatment of splenic injuries underwent major changes during the past decades, shifting from a surgical approach to nonoperative management. This change of the proceedings results from a constantly growing awareness of the spleen's crucial hematological and immunological function and was possible owing to the advances in radiological techniques.
View Article and Find Full Text PDFPurpose: The aim of this study was to evaluate the efficacy and safety of 177Lu-DOTA-IBA for pain palliation in participants with bone metastases and confirm its potential for treating bone metastasis.
Patients And Methods: Overall, 69 participants with bone metastases were included. 68Ga-DOTA-IBA PET/CT was performed within 1 week before treatment.
A whole gamma imaging prototype for higher quantitative imaging ofZr-labeled antibodies in a tumor mouse model.
Phys Med Biol
January 2025
Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology (QST), 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
Article Synopsis
- PET imaging using Zr is gaining traction for visualizing immune and cancer cells, but has limitations due to low image quality from gamma ray emissions.
- A new prototype has been developed to improve Compton imaging within PET by redesigning the scatter detector and optimizing image reconstruction methods.
- The upgraded WGI system showed enhanced imaging performance, including improved angular resolution, sensitivity, and reduced noise, demonstrating successful in-vivo imaging of a mouse with tumor burden after Zr labeled antibody injection.
RELATIONSHIP OF THE PERCEIVED STRESS LEVEL, ANTHROPOMETRIC INDICATORS AND BODY COMPOSITION IN CHILDREN EXPERIENCING PERMANENT NEGATIVE IMPACT OF THE COVID-19 PANDEMIC AND THE WAR IN UKRAINE.
Probl Radiac Med Radiobiol
December 2024
National University of Physical Education and Sport of Ukraine, 1 Fizkultury Str., Kyiv, 03150, Ukraine.
Objective: to assess the impact of stressful life events occuring with the period of restrictive measures introductionconnected to the COVID-19 pandemic and during the full-scale Russian aggression, on the anthropometric indicators and body composition of children aged 10-17 years.
Materials And Methods: The research group consisted of 56 boys and 70 girls aged 10-17 years who lived in radioactively contaminated areas of Zhytomyr, Rivne, and Kyiv regions with a soil contamination density of 137Cs from 18 kBq/m2 to 235 kBq/m2. The impact of stressful factors was assessed using the stress perception scale (PSS-10).
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