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The study of elastic fibres in oral precancerous and cancerous lesions using Shikata's modified orcein stain: a retrospective study.
Ecancermedicalscience
November 2024
Department of Public Health Dentistry, DY Patil University School of Dentistry, Nerul Navi Mumbai, Sector 7, Nerul, Navi Mumbai 400706, Maharashtra, India.
Statement Of The Problem: Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer. During the invasion, tumour cells break through the basement membrane and penetrate the connective tissue to interact with the extracellular matrix. An attempt was made to evaluate the connective tissue changes in different grades of OSCCs, oral submucous fibrosis (OSMF) and Oral Epithelial Dysplasias.
View Article and Find Full Text PDFUltrasound evaluation of kidney and liver involvement in Bardet-Biedl syndrome.
Orphanet J Rare Dis
November 2024
Children's Hospital, Pediatrics II, Pediatric Nephrology, University of Duisburg-Essen, Essen, Germany.
Background: Bardet-Biedl syndrome (BBS) is a rare autosomal-recessive ciliopathy with pathogenic variants in 26 BBS genes. It affects multiple organs, including the kidney and liver, with varying degrees regarding extent and time of first manifestation. Structural renal anomalies are an early feature and end-stage kidney disease (ESKD) cumulates to 25% in adulthood.
View Article and Find Full Text PDFA mathematical model for pancreatic cancer during intraepithelial neoplasia.
R Soc Open Sci
October 2024
Instituto de Investigaciones en Matemáticas Aplicadas y en Sistemas, Universidad Nacional Autónoma de México, Ciudad de Mexico, Mexico.
Article Synopsis
- Cancer results from complex interactions between internal and external cell processes, leading to continued cell growth and resistance to cell death.
- The study explores how the cellular microenvironment influences cancer development, focusing specifically on the early stages of pancreatic adenocarcinoma (PanIN 1 and PanIN 2).
- By creating a model that incorporates gene-regulatory networks and cell communication, the research highlights the role of inflammatory processes and suggests targeting the RAS oncogene as a potential anti-inflammatory strategy to prevent aggressive cancer forms.
Validation of metaxin-2 deficient C. elegans as a model for MandibuloAcral Dysplasia associated to mtx-2 (MADaM) syndrome.
Commun Biol
October 2024
Université Paris Cité, INSERM UMR 1141 "NeuroDiderot", FHU Iio2-D2, Paris, France.
Article Synopsis
- MandibuloAcral Dysplasia associated to MTX2 gene (MADaM) is an accelerated aging disease characterized by skin issues, growth delays, and heart-related problems.
- Research using mtx-2-deficient C. elegans (a type of worm) shows they exhibit similar aging characteristics to humans with MADaM, including rougher skin texture and poor mitochondrial function.
- The findings from various analyses support these worms as a promising model to explore MADaM's molecular mechanisms and help develop potential treatments.
Aortic aneurysm: Correlations with phenotypes associated with connective tissue dysplasia.
Microvasc Res
January 2025
I.M. Sechenov First Moscow State Medical University (Sechenov University), Department of Human Anatomy and Histology, Moscow, Russia.
An aortic aneurysm is a localized enlargement that exceeds the normal diameter of the vessel by 50 %, posing a risk due to the likelihood of rupture. The cause of aortic aneurysm, especially in young people, is connective tissue dysplasia, a condition characterized by defects in the assembly of collagen and elastin proteins, leading to changes in elastic properties and disruption of the formation of organs and their systems. The article presents data confirming the relationship between many morphological manifestations of connective tissue dysplasia (e.
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