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Intact N-glycopeptide analysis of human platelets reveals a Glycostructure important for platelet function.
Glycobiology
January 2025
Institute of Blood Transfusion, Shanghai Blood Center, 1191 Hongqiao Road, Shanghai 200051, China.
Glycosylation is an important posttranslational modification in platelets, and the glycosylation pattern is critical for platelet function. To date, the exploration of the roles of various glycoforms in specific platelet functions is largely lacking. In this study, a global analysis of intact N-glycopeptides in human platelets was performed to map all the glycopeptides, glycosites and glycans of platelets.
View Article and Find Full Text PDFEfficient and green extraction of chitin from Hermetia illucens using deep eutectic solvents and its application for rapid hemostasis.
Carbohydr Polym
March 2025
State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China; Quzhou Institute for Innovation in Resource Chemical Engineering, Quzhou 324000, China. Electronic address:
Hermetia illucens, with a short growth cycle, is promising as a valuable source of chitin. However, the optimal method for extracting chitin from this insect and its application for hemostasis has not been addressed. This work employed an environmentally friendly choline chloride-lactic acid deep eutectic solvent technology to extract chitin effectively from the Hermetia illucens pupae shells, realizing one-step removal of inorganic salts and proteins.
View Article and Find Full Text PDFDevelopment of a Highly Hydrophobic Micro/Nanostructured Nanocomposite Coating of PLA-PEG-Cloisite 20A Nanoclay with Excellent Hemocompatibility and Rapid Endothelialization Properties for Cardiovascular Applications.
ACS Appl Mater Interfaces
January 2025
Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran 1416753955, Iran.
Despite the unique properties of clay nanocomposites for cardiovascular applications, there are few data on the hemocompatibility of these nanomaterials. This study represents the first comprehensive investigation of the hemo/biocompatibility of clay nanocomposites . Nanocomposite coatings of polylactic acid (PLA)-polyethylene glycol (3 wt %)-Cloisite20A nanoclay (3 wt %) were produced using electrospraying technique as potential drug-eluting stent (DES) coatings.
View Article and Find Full Text PDFUnraveling the mystery: effect of trapped air on platelet adhesion on hydrophobic nanostructured titanium dioxide.
Biomater Sci
January 2025
Research Institute for Biomimetics and Soft Matter, Fujian Provincial Key Laboratory for Soft Functional Materials Research, Department of Physics, College of Physical Science and Technology, Xiamen University, Xiamen 361005, China.
Nature-inspired superhydrophobic materials have attracted considerable interest in blood-contacting biomedical applications due to their remarkable water-repellent and self-cleaning properties. However, the interaction mechanism between blood components and superhydrophobic surfaces remains unclear. To explore the effect of trapped air on platelet adhesion, we designed four distinct hydrophobic titanium dioxide (TiO) nanostructures with different fractions of trapped air.
View Article and Find Full Text PDFIncreased Platelet Adhesiveness in Patients with Venous Thromboembolic Disease.
TH Open
October 2024
Thrombosis and Haemostasis Unit, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Association between global platelet function and the risk of venous thromboembolic disease (VTE) has been proposed, though the mechanisms do not involve increased platelet aggregation. However, platelet adhesiveness has not been systematically explored in VTE patients. To evaluate platelet adhesive functions in VTE patients.
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